{"id":"W4386530996","doi":"10.1128/mbio.00946-23","title":"<i>Mycobacterium tuberculosis</i> carrying the rifampicin drug-resistance-conferring <i>rpoB</i> mutation H445Y is associated with suppressed immunity through type I interferons","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada); McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; Georgia Clinical and Translational Science Alliance; National Center for Research Resources; Alvin J. Siteman Cancer Center","keywords":"rpoB; Mycobacterium tuberculosis; Rifampicin; Drug resistance; Tuberculosis; Virology; Microbiology; Immunity; Mutation; Biology; Drug; Immunology; Medicine; Antibiotics; Genetics; Immune system; Pharmacology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009291223,0.000284428,0.0005429047,0.0001154833,0.0004005426,0.00006485281,0.0002759184,0.0001677704,0.0001395812],"category_scores_gemma":[0.001024309,0.0001892167,0.0001443934,0.0009422296,0.0002444106,0.0001905596,0.0001533709,0.0007583582,0.0002409691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002029584,"about_ca_system_score_gemma":0.000163955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001271737,"about_ca_topic_score_gemma":0.001479607,"domain_scores_codex":[0.9974276,0.0004980172,0.0004278267,0.0004325437,0.000407219,0.0008068258],"domain_scores_gemma":[0.9979212,0.0007948877,0.0001319002,0.000679318,0.0003137842,0.0001588882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.003680039,0.000608783,0.2108078,0.0006932733,0.003194301,0.0006063444,0.02470972,0.0001008502,0.1907418,0.0006381667,0.5631519,0.001067014],"study_design_scores_gemma":[0.01003347,0.00141483,0.7700538,0.002492244,0.001269827,0.000223231,0.008743655,0.002336748,0.09140664,0.001697119,0.1087183,0.0016101],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699056,0.0003614888,0.000038795,0.02189892,0.0002915708,0.0005906617,0.00005887371,0.0003082048,0.006545908],"genre_scores_gemma":[0.9916052,0.0003127922,0.00008578134,0.003950717,0.0001457071,0.00007979895,0.0004696049,0.00005790623,0.003292487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5592461,"threshold_uncertainty_score":0.7716033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03706808926698425,"score_gpt":0.3103274077820636,"score_spread":0.2732593185150793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}