{"id":"W4386530996","doi":"10.1128/mbio.00946-23","title":"<i>Mycobacterium tuberculosis</i> carrying the rifampicin drug-resistance-conferring <i>rpoB</i> mutation H445Y is associated with suppressed immunity through type I interferons","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada); McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; Georgia Clinical and Translational Science Alliance; National Center for Research Resources; Alvin J. Siteman Cancer Center","keywords":"rpoB; Mycobacterium tuberculosis; Rifampicin; Drug resistance; Tuberculosis; Virology; Microbiology; Immunity; Mutation; Biology; Drug; Immunology; Medicine; Antibiotics; Genetics; Immune system; Pharmacology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001259194,0.000285711,0.0002294861,0.0001872133,0.0001355874,0.0002230662,0.0001238,0.0003194228,0.001240849],"category_scores_gemma":[0.0001202514,0.0001372756,0.0002404816,0.00009892248,0.00024951,0.00007051355,0.0001450885,0.0004843066,0.0003669297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001048121,"about_ca_system_score_gemma":0.0000707748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002709083,"about_ca_topic_score_gemma":0.0002786163,"domain_scores_codex":[0.9997972,0.00004703226,0.00002641685,0.00004655655,0.00004042119,0.00004241388],"domain_scores_gemma":[0.9997653,0.0000307307,0.0001198818,0.0000201455,0.00001297927,0.00005096036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001770052,0.000040363,0.001032694,0.00001357019,0.000005930287,0.0002084412,0.000008152783,0.00001565716,0.9981807,0.00001927502,0.00003658231,0.0002614893],"study_design_scores_gemma":[0.00007403632,0.00254393,0.1341554,0.00002375562,0.00007099257,0.009776239,0.0001584577,0.001351876,0.8487564,0.0001038922,0.002966308,0.00001873982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987382,0.0002924777,0.0003266582,0.00005658039,0.0000152803,0.000009580174,0.0001626082,0.00001918519,0.0003796019],"genre_scores_gemma":[0.9989248,0.0001104154,0.0002376346,0.00005428682,0.00001598525,0.000009559255,0.0002512424,0.000008275656,0.000387889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001240849,"threshold_uncertainty_score":0.004151046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03706808926698425,"score_gpt":0.3103274077820636,"score_spread":0.2732593185150793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}