{"id":"W4386531447","doi":"10.1158/2159-8290.cd-23-0383","title":"SHP2: A Pleiotropic Target at the Interface of Cancer and Its Microenvironment","year":2023,"lang":"en","type":"review","venue":"Cancer Discovery","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Institutes of Health; National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; Foundation for the National Institutes of Health","keywords":"Tumor microenvironment; Cancer; Cancer research; Phosphatase; Regulator; Biology; Master regulator; Cancer therapy; Cancer cell; Phosphorylation; Cell biology; Tumor cells; Transcription factor; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002878378,0.0005733477,0.0007180459,0.001135016,0.0001924558,0.0007482825,0.0005040332,0.000716973,0.002779349],"category_scores_gemma":[0.000295277,0.0001662907,0.0003101933,0.001174691,0.0002915212,0.0008967018,0.0004987134,0.001509495,0.001592949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004811239,"about_ca_system_score_gemma":0.0007425274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005792161,"about_ca_topic_score_gemma":0.001392204,"domain_scores_codex":[0.9999149,0.00001261806,0.000007276806,0.00001350893,0.00003743888,0.0000143127],"domain_scores_gemma":[0.9999053,0.00003530994,0.00001343416,0.000003139506,0.00002809508,0.00001459973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001029149,0.00005768517,0.0002000781,0.01250577,0.00009142647,0.0003098625,0.00005953066,0.0004829284,0.007567673,0.006284645,0.04071669,0.9316209],"study_design_scores_gemma":[0.00001285504,0.00007372625,0.0004979188,0.001161409,0.00005557014,0.00107759,0.00003379399,0.00007994571,0.0009058592,0.001611127,0.9944797,0.00001054703],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002383895,0.9974975,0.000173859,0.0003738623,0.0002590219,0.000003709154,0.00002322326,0.0000105714,0.001419851],"genre_scores_gemma":[0.001194719,0.9971654,0.0001596464,0.0002674527,0.0001411371,0.000004925319,0.00003687949,0.000001544132,0.0010284],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002779349,"threshold_uncertainty_score":0.009297788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486883676458796,"score_gpt":0.3391070805643569,"score_spread":0.3142382437997689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}