{"id":"W4386531447","doi":"10.1158/2159-8290.cd-23-0383","title":"SHP2: A Pleiotropic Target at the Interface of Cancer and Its Microenvironment","year":2023,"lang":"en","type":"review","venue":"Cancer Discovery","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Institutes of Health; National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; Foundation for the National Institutes of Health","keywords":"Tumor microenvironment; Cancer; Cancer research; Phosphatase; Regulator; Biology; Master regulator; Cancer therapy; Cancer cell; Phosphorylation; Cell biology; Tumor cells; Transcription factor; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006531779,0.0003166992,0.0005998446,0.00002520703,0.0000564615,0.00002425192,0.0003268821,0.0001579567,0.00006874045],"category_scores_gemma":[0.00002589191,0.0002109981,0.0002026802,0.00008223641,0.0001495254,0.000005505606,0.000786553,0.0001275837,0.00001423711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001269046,"about_ca_system_score_gemma":0.0002290754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000157951,"about_ca_topic_score_gemma":0.0002304053,"domain_scores_codex":[0.9987734,0.00005573105,0.0003222369,0.0004866454,0.0001204739,0.0002415116],"domain_scores_gemma":[0.9991754,0.00002279515,0.0002967477,0.0004443453,0.00001418519,0.00004658211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003077374,0.0001663814,0.0005518485,0.07707822,0.005158305,0.00002500639,0.0001230123,0.0004172457,0.03528267,0.0003548904,0.1022312,0.7783035],"study_design_scores_gemma":[0.0001340034,0.00004807048,0.00003815094,0.003318445,0.000318809,0.000003618708,0.00000514824,8.957424e-7,0.07483311,0.000006349308,0.9210649,0.0002285564],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001873364,0.9934466,0.00001811143,0.00007779698,0.0002829739,0.0006967146,0.003589083,0.000005530433,0.000009839151],"genre_scores_gemma":[0.000294245,0.9925663,0.000009574432,0.0000643221,0.0002394727,0.0007216232,0.0003194516,0.00006678794,0.00571817],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8188336,"threshold_uncertainty_score":0.8604251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486883676458796,"score_gpt":0.3391070805643569,"score_spread":0.3142382437997689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}