{"id":"W4386537550","doi":"10.1093/neuonc/noad137.155","title":"P06.15.B IMMUNOTHERAPEUTIC TARGETING OF FIBROBLAST ACTIVATION PROTEIN (FAP) IN TREATMENT REFRACTORY GLIOBLASTOMA USING NOVEL CAR-T CELL THERAPY","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Fibroblast activation protein, alpha; Chimeric antigen receptor; Cancer research; Stromal cell; Medicine; Glioma; Antigen; U87; Immunology; Immunotherapy; Cancer; Internal medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001423421,0.0002654567,0.0003305275,0.0002293995,0.0001402511,0.0002926133,0.0002730744,0.0004910635,0.001966059],"category_scores_gemma":[0.00005491629,0.00007743414,0.0002312788,0.0001483403,0.0001625421,0.0001370151,0.0001353359,0.0004578199,0.0006214248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002219727,"about_ca_system_score_gemma":0.0003180957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006499066,"about_ca_topic_score_gemma":0.0005199956,"domain_scores_codex":[0.9999379,0.000008577503,0.000003905576,0.00001197693,0.00001582368,0.00002173846],"domain_scores_gemma":[0.9999776,0.000002249859,0.000004929676,0.000002305305,0.000003868727,0.000009117319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00102387,0.0006154059,0.000537818,0.0002911475,0.00002691723,0.0007361396,0.0000658666,0.001150935,0.955191,0.00114057,0.002164025,0.03705633],"study_design_scores_gemma":[0.0004284528,0.006277317,0.004075839,0.00005253212,0.0001158571,0.004133146,0.00005632344,0.009589239,0.9326175,0.0004258546,0.04220765,0.00002036925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697345,0.009038177,0.01102782,0.000529772,0.0002649844,0.0003263466,0.0006843046,0.0003705716,0.008023568],"genre_scores_gemma":[0.9848363,0.002473473,0.005801713,0.0001627888,0.00004238353,0.0002151127,0.0007234667,0.000027636,0.00571712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001966059,"threshold_uncertainty_score":0.006577134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05777059559807561,"score_gpt":0.3468138788377503,"score_spread":0.2890432832396747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}