{"id":"W4386537711","doi":"10.1093/neuonc/noad137.173","title":"P07.13.B A RANDOMIZED STUDY OF LOW-INTENSITY FOCUSED ULTRASOUND FOR BLOOD-BRAIN BARRIER DISRUPTION FOR BRAIN METASTASIS FROM NON-SMALL CELL LUNG CANCER (LIMITLESS)","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Pembrolizumab; Lung cancer; Brain metastasis; Internal medicine; Microbubbles; Oncology; Randomized controlled trial; Cancer; Metastasis; Immunotherapy; Ultrasound; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00302422,0.00153017,0.002690656,0.0004992392,0.0004354595,0.001424774,0.000791251,0.002530814,0.0153623],"category_scores_gemma":[0.003065357,0.0007033314,0.002355985,0.0003747261,0.001141228,0.00125393,0.000621127,0.002678805,0.001360488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000656958,"about_ca_system_score_gemma":0.001302335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006047984,"about_ca_topic_score_gemma":0.000767737,"domain_scores_codex":[0.9983705,0.0009853679,0.0001135662,0.0002696304,0.00009279983,0.0001682198],"domain_scores_gemma":[0.9982901,0.0005884008,0.0003873525,0.000150192,0.0001673563,0.0004165706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9867737,0.003228561,0.0002986228,0.000586077,0.0009811156,0.00001568722,0.00001422697,0.0001136,0.001360004,0.0001794942,0.0007755234,0.005673361],"study_design_scores_gemma":[0.9416271,0.05531674,0.0007355012,0.00005198978,0.0006986528,0.000012907,0.00001140336,0.0002996914,0.0002410195,0.0002181503,0.0007774577,0.00000946916],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9522354,0.009760164,0.00239759,0.0022519,0.002515354,0.02178226,0.003228345,0.0004024194,0.005426651],"genre_scores_gemma":[0.9584264,0.002001195,0.004361887,0.002372905,0.0009818067,0.02351195,0.001490047,0.00005178405,0.006802122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0153623,"threshold_uncertainty_score":0.05139196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01786350195217159,"score_gpt":0.276954727855032,"score_spread":0.2590912259028604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}