{"id":"W4386537738","doi":"10.1093/neuonc/noad137.263","title":"P11.29.B UPDATE ON GBM AGILE: A GLOBAL, PHASE 2/3 ADAPTIVE PLATFORM TRIAL TO EVALUATE MULTIPLE REGIMENS IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Agile software development; Medicine; Biomarker; Glioblastoma; Randomization; Clinical trial; Oncology; Internal medicine; Medical physics; Computer science; Cancer research; Biology; Software engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005870843,0.0008685879,0.001478427,0.0005647388,0.0003997333,0.001403339,0.0007998119,0.001380746,0.008498062],"category_scores_gemma":[0.00439183,0.0002551613,0.001726848,0.0006734745,0.0005114677,0.001001161,0.0007392865,0.003584065,0.001827253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007785154,"about_ca_system_score_gemma":0.001777241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009301397,"about_ca_topic_score_gemma":0.003022678,"domain_scores_codex":[0.9987149,0.0008228011,0.00006571868,0.0001051476,0.0001801997,0.0001111511],"domain_scores_gemma":[0.9969753,0.001069561,0.000428096,0.0002126769,0.0004311344,0.0008831787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1017704,0.005568142,0.004933239,0.003131224,0.002031125,0.0004357913,0.0002513663,0.004458791,0.01456463,0.003716724,0.198807,0.6603315],"study_design_scores_gemma":[0.4129469,0.1364181,0.03526768,0.002835814,0.002935347,0.001365055,0.000198839,0.007087168,0.01023849,0.01286685,0.377625,0.0002148632],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5674363,0.08127967,0.04181219,0.07491204,0.008136044,0.03009451,0.07144111,0.004652793,0.1202352],"genre_scores_gemma":[0.7241029,0.0379872,0.05697153,0.05817259,0.003406027,0.03319443,0.04229083,0.001594498,0.04228001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008498062,"threshold_uncertainty_score":0.03104842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05586208752735044,"score_gpt":0.3697767566920936,"score_spread":0.3139146691647431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}