{"id":"W4386537845","doi":"10.1007/s12017-023-08754-1","title":"Dysregulated COMT Expression in Fragile X Syndrome","year":2023,"lang":"en","type":"article","venue":"NeuroMolecular Medicine","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Weill Cornell Medical College; BC Children's Hospital; Michael Smith Health Research BC; FRAXA Research Foundation","keywords":"Fragile X syndrome; FMR1; Catechol-O-methyl transferase; Dopamine; Neuroscience; Dopaminergic; Intellectual disability; Autism; Autism spectrum disorder; Norepinephrine; Biology; Psychology; Internal medicine; Endocrinology; Fragile x; Medicine; Allele; Genetics; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000808176,0.0002848255,0.0001871534,0.0005011456,0.0001772597,0.0003365254,0.0001182519,0.0003112725,0.002111375],"category_scores_gemma":[0.0002513708,0.0001142757,0.0001430756,0.0002387754,0.0002381184,0.0001265818,0.0001650085,0.0002347745,0.0002440342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002131926,"about_ca_system_score_gemma":0.0001151168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007692119,"about_ca_topic_score_gemma":0.0006020347,"domain_scores_codex":[0.9999068,0.00001304507,0.00001055294,0.00002708763,0.0000267528,0.00001571825],"domain_scores_gemma":[0.9998759,0.00003070925,0.00004439952,0.000008644785,0.00001114703,0.00002922305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004180683,0.00001148788,0.006065093,0.0000288388,0.00002215984,0.002403077,0.00004548348,0.0001444035,0.9863818,0.0003166035,0.0001872562,0.003975903],"study_design_scores_gemma":[0.00004249673,0.000246167,0.1926589,0.00002173663,0.00007771421,0.01648241,0.0002240857,0.001994189,0.782679,0.0007613027,0.004793599,0.000018523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963068,0.0009860049,0.0009337284,0.0001595671,0.00003392375,0.000003189768,0.0004137975,0.0000523074,0.001110571],"genre_scores_gemma":[0.9976489,0.0003044975,0.0005737648,0.00003970644,0.00001504745,0.000004398836,0.000213635,0.00001842326,0.001181577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002111375,"threshold_uncertainty_score":0.00706327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107540289623909,"score_gpt":0.2417352274354483,"score_spread":0.2309811984730574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}