{"id":"W4386545230","doi":"10.1101/2023.09.07.556717","title":"The oral pathogen <i>Porphyromonas gingivalis</i> resists the antimicrobial peptide LGL13K and evades the D-enantiomer by synonymous mutations in <i>hagA</i>","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Concordia University; University of Louisville; University of Minnesota","keywords":"Porphyromonas gingivalis; Microbiology; Antimicrobial; Biology; Bacteria; Virulence; Mutant; Hemagglutinin (influenza); Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007659238,0.000280543,0.0001393948,0.000095264,0.0001248692,0.0002435041,0.0001920657,0.000202216,0.0006940084],"category_scores_gemma":[0.0001073855,0.00009536371,0.0001866583,0.00008414219,0.0001521977,0.00009486549,0.0002887284,0.0003412028,0.0002913848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002039432,"about_ca_system_score_gemma":0.0001523896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001200616,"about_ca_topic_score_gemma":0.001102275,"domain_scores_codex":[0.9998789,0.00001545014,0.00001648948,0.00002166797,0.00003884369,0.00002868727],"domain_scores_gemma":[0.9999285,0.000009919514,0.00002708837,0.0000123341,0.00000675241,0.00001535898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002214199,0.000007390211,0.0002033677,0.000007891568,0.000001372784,0.00003778881,0.000005012102,0.00001559602,0.9993775,0.00001781123,0.00001121369,0.0002928442],"study_design_scores_gemma":[0.000008228887,0.0002382989,0.01381337,0.000008428465,0.00001597542,0.0009052718,0.00007183728,0.0008400051,0.9824905,0.00004775164,0.00155263,0.00000773494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986487,0.0001643462,0.0005239282,0.00005129143,0.000006956192,0.00000829541,0.0001514414,0.00002138541,0.0004236334],"genre_scores_gemma":[0.9978911,0.00008604048,0.0009052467,0.00003164956,0.000002278034,0.000008639696,0.0002769528,0.00001290576,0.0007851865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200616,"threshold_uncertainty_score":0.002387285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286721701072833,"score_gpt":0.215063027278089,"score_spread":0.2021958102673606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}