{"id":"W4386545440","doi":"10.1101/2023.09.06.556620","title":"Immunogenicity and tolerability of a SARS-CoV-2 TNX-1800, a live recombinant poxvirus vaccine candidate, in Syrian Hamsters and New Zealand White Rabbits","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Immunogenicity; Tolerability; Virology; Medicine; Dosing; Mesocricetus; Hamster; Biology; Immunology; Pharmacology; Antibody; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005392036,0.0004179751,0.0004646423,0.0003457021,0.0001817796,0.000355611,0.00012566,0.0004918029,0.0008405773],"category_scores_gemma":[0.0004217023,0.0002005585,0.0005113751,0.0001334887,0.0004901483,0.0004257786,0.0001603465,0.0006698058,0.0003609816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000289093,"about_ca_system_score_gemma":0.0001476855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008710988,"about_ca_topic_score_gemma":0.000556996,"domain_scores_codex":[0.9997278,0.00006011992,0.00003168714,0.00007033788,0.00005664547,0.00005346667],"domain_scores_gemma":[0.9996673,0.00005793757,0.0001081082,0.0000547973,0.00004173731,0.00007015302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003680694,0.0008672643,0.003307935,0.00005140966,0.00003643228,0.000124344,0.0002434592,0.0001525794,0.9888988,0.00006618429,0.00006496275,0.002505887],"study_design_scores_gemma":[0.0005816719,0.1265642,0.1240028,0.00003194351,0.0002695096,0.001159443,0.0004694588,0.00153501,0.7435893,0.000149873,0.001602842,0.00004395003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994173,0.0001353795,0.0001187947,0.0000127265,0.00000805453,0.00001421344,0.00008386891,0.000005764432,0.0002038253],"genre_scores_gemma":[0.9978324,0.0002097462,0.0002120312,0.00003945271,0.00001356299,0.00003727172,0.0002855686,0.000007286019,0.001362712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008710988,"threshold_uncertainty_score":0.002851605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04169781407912636,"score_gpt":0.2958901039742072,"score_spread":0.2541922898950809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}