{"id":"W4386557984","doi":"10.1093/neuonc/noad137.011","title":"KS02.6.A INDIGO: A GLOBAL, RANDOMIZED, DOUBLE-BLINDED, PHASE III STUDY OF VORASIDENIB VERSUS PLACEBO IN PATIENTS WITH RESIDUAL OR RECURRENT GRADE 2 GLIOMA WITH AN IDH1/2 MUTATION","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Medicine; Internal medicine; Glioma; Interim analysis; Randomized controlled trial; Clinical endpoint; Placebo; Randomization; Hazard ratio; Surgery; Oncology; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001503817,0.002223027,0.002802151,0.000853362,0.0004113735,0.00130917,0.001225144,0.00178454,0.008829172],"category_scores_gemma":[0.0009405549,0.0008743239,0.001561862,0.000649457,0.001500909,0.00110961,0.0004330402,0.003048326,0.001814828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006988275,"about_ca_system_score_gemma":0.001881925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009065027,"about_ca_topic_score_gemma":0.002865777,"domain_scores_codex":[0.9995315,0.0002386031,0.00002177898,0.00008266341,0.00003242859,0.00009297909],"domain_scores_gemma":[0.9995916,0.00006934514,0.0000856059,0.00002971079,0.00003018158,0.0001935622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9554925,0.01291127,0.0004390878,0.001018698,0.0007090611,0.00004879135,0.00006963609,0.0004192505,0.008255969,0.0001802121,0.001676537,0.018779],"study_design_scores_gemma":[0.940987,0.05640187,0.0008581615,0.00002486969,0.000252492,0.00003006743,0.0000212216,0.000279532,0.0004645461,0.0001069702,0.0005598054,0.00001347636],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717809,0.006668049,0.001247197,0.001171917,0.0007799446,0.009061423,0.003243733,0.0006042841,0.005442513],"genre_scores_gemma":[0.9734859,0.003906083,0.002016003,0.001872929,0.0003535636,0.008831832,0.002124451,0.0000625696,0.007346596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008829172,"threshold_uncertainty_score":0.02953655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0548570023581767,"score_gpt":0.3746291240748868,"score_spread":0.3197721217167101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}