{"id":"W4386559548","doi":"10.3389/fphar.2023.1235255","title":"A type II cannabis extract and a 1:1 blend of Δ(9)-tetrahydrocannabinol and cannabidiol display distinct antinociceptive profiles and engage different endocannabinoid targets when administered into the subarachnoid space","year":2023,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université de Montréal","keywords":"Cannabidiol; TRPV1; Pharmacology; Endocannabinoid system; Capsazepine; Cannabinoid receptor; AM251; Cannabis; Cannabinoid; Nociception; Tetrahydrocannabinol; Chemistry; Medicine; Receptor; Agonist; Biochemistry; Transient receptor potential channel; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007444235,0.0003900293,0.0002241442,0.0003872271,0.0001776442,0.0002583451,0.0001899986,0.0002261383,0.002069424],"category_scores_gemma":[0.0001284836,0.0001020982,0.000215054,0.0002135481,0.0002614689,0.0002025923,0.0001727785,0.0003665476,0.0002962112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002653565,"about_ca_system_score_gemma":0.0003397613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107436,"about_ca_topic_score_gemma":0.001821466,"domain_scores_codex":[0.9998908,0.000008581665,0.000008600951,0.00002109144,0.0000490832,0.00002180489],"domain_scores_gemma":[0.9999416,0.000007226109,0.00001498829,0.000004893684,0.00001029387,0.00002102961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007556533,0.0001475268,0.0003632768,0.00008183865,0.00001906492,0.00007124437,0.00001519228,0.00007660386,0.9951651,0.00007747551,0.0000710094,0.003155904],"study_design_scores_gemma":[0.00009484673,0.004815865,0.008016313,0.00003724002,0.0001155458,0.0004390766,0.00008553421,0.0005828164,0.9812703,0.00007684981,0.00444518,0.0000203968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995144,0.001234797,0.001006141,0.00008276495,0.00007413259,0.0001071871,0.0003673242,0.00003951333,0.001944062],"genre_scores_gemma":[0.9926202,0.001384738,0.002241583,0.00009772364,0.00002965456,0.00007453861,0.0004535947,0.0000153296,0.0030825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002069424,"threshold_uncertainty_score":0.006922901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01413042652448845,"score_gpt":0.3000752946724791,"score_spread":0.2859448681479907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}