{"id":"W4386560158","doi":"10.1016/j.celrep.2023.113023","title":"MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Ludwig Center at Harvard; Genentech; Québec Consortium for Drug Discovery; National Institutes of Health; Ontario Genomics; University of Toronto; A Breath of Hope Lung Foundation; School of Medicine, Stanford University; Massachusetts Institute of Technology; Fondation Brain Canada; Valhalla Foundation; Cancer Research Society; U.S. Department of Defense; Genome Canada; Broad Institute; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; American Society of Clinical Oncology; AstraZeneca; University of Texas Southwestern Medical Center; Virginia and D.K. Ludwig Fund for Cancer Research; Jane Coffin Childs Memorial Fund for Medical Research; Conquer Cancer Foundation; University of Regina","keywords":"Phosphatidylinositol; Arachidonic acid; Polyunsaturated fatty acid; Cell biology; Biochemistry; Phospholipid; Chemistry; Enzyme; Biology; Fatty acid; Signal transduction; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003792544,0.0002604215,0.0004497999,0.0001556368,0.0001611801,0.00009946174,0.00004371836,0.0001082478,0.00003670542],"category_scores_gemma":[0.0001355527,0.000202406,0.00003357584,0.001271898,0.00005831451,0.0000934999,0.000104027,0.0001425081,0.00001219859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007879838,"about_ca_system_score_gemma":0.0001907115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001738682,"about_ca_topic_score_gemma":0.00007519661,"domain_scores_codex":[0.9979853,0.00002070969,0.0004225563,0.0008179463,0.0003466197,0.0004068403],"domain_scores_gemma":[0.99844,0.00003056544,0.0001236479,0.0004782332,0.0003979742,0.0005295535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001280763,0.0003052941,0.4332248,0.0007602131,0.0001320997,0.001099725,0.004242451,0.000221685,0.4977621,0.000006290344,0.01370699,0.04725761],"study_design_scores_gemma":[0.001083128,0.001823819,0.2407255,0.0007354087,0.0002805857,0.0002929646,0.001195733,0.0007891798,0.7361526,0.00002868609,0.0162414,0.0006509664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943756,0.0006126777,0.00002807323,0.002547933,0.0001466537,0.001352659,0.00000861658,0.0002106586,0.0007171049],"genre_scores_gemma":[0.9951524,0.0002236263,0.002377616,0.0006047562,0.00006997673,0.0000958616,0.00002739098,0.00004944453,0.001398896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2383906,"threshold_uncertainty_score":0.8253878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154500784719991,"score_gpt":0.2656089263462723,"score_spread":0.2501588478742732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}