{"id":"W4386564493","doi":"10.1016/s2468-1253(23)00208-x","title":"Efficacy and safety of upadacitinib maintenance therapy for moderately to severely active ulcerative colitis in patients responding to 8 week induction therapy (U-ACHIEVE Maintenance): overall results from the randomised, placebo-controlled, double-blind, phase 3 maintenance study","year":2023,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"AbbVie","keywords":"Medicine; Ulcerative colitis; Maintenance therapy; Placebo; Population; Clinical endpoint; Internal medicine; Clinical trial; Intention-to-treat analysis; Phases of clinical research; Adverse effect; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001218218,0.0006689723,0.002420762,0.0002522615,0.000244109,0.0007733171,0.000642488,0.001096388,0.002457676],"category_scores_gemma":[0.000993857,0.0002967706,0.001449167,0.0003227613,0.0005841723,0.0007510565,0.0002692801,0.001895444,0.0004565039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004994572,"about_ca_system_score_gemma":0.0004546753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006529027,"about_ca_topic_score_gemma":0.001335479,"domain_scores_codex":[0.9996629,0.0001467513,0.00002639608,0.00004592074,0.00003846596,0.00007956215],"domain_scores_gemma":[0.9992817,0.0002008973,0.0002044086,0.00006453914,0.00005036063,0.0001980454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9080334,0.002658108,0.002636489,0.001193816,0.001729215,0.00007918874,0.00007084446,0.0004610889,0.008924057,0.0000694554,0.001249726,0.07289466],"study_design_scores_gemma":[0.7743082,0.1794853,0.03848339,0.0001512114,0.002314975,0.0002852036,0.00007057743,0.0007314035,0.002286527,0.0001807616,0.001653298,0.00004912132],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880113,0.009570586,0.0001985508,0.0002610033,0.0001216976,0.0003245785,0.0005236754,0.00006407656,0.000924595],"genre_scores_gemma":[0.9947983,0.002524504,0.0002915293,0.0003735853,0.0001362963,0.0002302936,0.0007800902,0.0000105804,0.0008549675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002457676,"threshold_uncertainty_score":0.008221745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0298605760607483,"score_gpt":0.2969115181333754,"score_spread":0.2670509420726271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}