{"id":"W4386564493","doi":"10.1016/s2468-1253(23)00208-x","title":"Efficacy and safety of upadacitinib maintenance therapy for moderately to severely active ulcerative colitis in patients responding to 8 week induction therapy (U-ACHIEVE Maintenance): overall results from the randomised, placebo-controlled, double-blind, phase 3 maintenance study","year":2023,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"AbbVie","keywords":"Medicine; Ulcerative colitis; Maintenance therapy; Placebo; Population; Clinical endpoint; Internal medicine; Clinical trial; Intention-to-treat analysis; Phases of clinical research; Adverse effect; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001774487,0.0005456989,0.001200909,0.0002774239,0.0003198227,0.00004451664,0.0006754615,0.0002567577,0.000007423773],"category_scores_gemma":[0.0003816549,0.0003794648,0.0002090607,0.000329332,0.0003561956,0.00002999867,0.0002625849,0.000415634,0.000006988638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001165355,"about_ca_system_score_gemma":0.0001459006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001439021,"about_ca_topic_score_gemma":0.001982252,"domain_scores_codex":[0.9946604,0.001652126,0.001105905,0.00117938,0.0002418363,0.001160358],"domain_scores_gemma":[0.9973796,0.000585531,0.0005744546,0.0008710542,0.0004038542,0.0001854883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9711418,0.0007093029,0.01798224,0.00000618478,0.0006219344,0.00004358778,0.002579351,0.0007212851,0.001661186,0.00006918382,0.002943652,0.001520285],"study_design_scores_gemma":[0.5226818,0.005964441,0.4681125,0.00004196698,0.00004451126,0.00001102806,0.0006974239,0.0004248259,0.0004180353,0.0001669223,0.001190547,0.0002460535],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982777,0.00002252539,0.001061811,0.003051128,0.0004505736,0.01109701,0.001448862,0.00003657486,0.00005454065],"genre_scores_gemma":[0.9922998,0.000234187,0.0001274425,0.003657077,0.0002951802,0.002773693,0.0003896574,0.00006572292,0.0001572588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4501303,"threshold_uncertainty_score":0.9998657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0298605760607483,"score_gpt":0.2969115181333754,"score_spread":0.2670509420726271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}