{"id":"W4386572774","doi":"10.1101/2023.09.07.556635","title":"Identification of an H-Ras nanocluster disrupting peptide","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université de Montréal; Centre National de la Recherche Scientifique; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fonds National de la Recherche Luxembourg","keywords":"Nanoclusters; HRAS; MAPK/ERK pathway; Cell biology; Peptide; Protein–protein interaction; Plasma protein binding; Chemistry; Signal transduction; Biophysics; Cancer research; Biology; Mutation; Biochemistry; KRAS; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008628994,0.0004277098,0.0006342838,0.0002986189,0.0001876455,0.00005599515,0.0006774494,0.0009808164,0.0001018484],"category_scores_gemma":[0.0002137552,0.0004433116,0.0001837607,0.0003252538,0.0002650582,0.0001100669,0.0005286862,0.0007610894,0.0003810641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000130662,"about_ca_system_score_gemma":0.0003139628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001857363,"about_ca_topic_score_gemma":0.00001931903,"domain_scores_codex":[0.9971783,0.0003262367,0.0008685393,0.0009969227,0.00007866764,0.0005513197],"domain_scores_gemma":[0.9973238,0.00008248393,0.0008287068,0.001309429,0.0003965156,0.00005910452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004791931,0.000104426,0.005759412,0.0002249802,0.0002269183,0.000008380031,0.00002834956,0.00003533224,0.99299,0.000222774,0.0003446529,0.000006892193],"study_design_scores_gemma":[0.0005097474,0.000107526,0.1836125,0.000182125,0.0001373008,6.341224e-8,0.00001779641,0.00004141784,0.812204,0.000006605733,0.002661326,0.0005196297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932976,0.001137356,0.0005052901,0.0001199922,0.00368011,0.0004723913,0.0003778536,0.0004014781,0.000007915487],"genre_scores_gemma":[0.9988866,0.0001585623,0.0002701522,0.00006731218,0.000207498,0.0001666354,0.000004743975,0.0001098198,0.0001287097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1807859,"threshold_uncertainty_score":0.9998019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723512037020663,"score_gpt":0.2452389474906365,"score_spread":0.2280038271204299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}