{"id":"W4386574738","doi":"10.1016/j.jcyt.2023.07.012","title":"Automated production of gene-modified chimeric antigen receptor T cells using the Cocoon Platform","year":2023,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Octane (Canada)","funders":"National Cancer Institute; McMaster University","keywords":"Chimeric antigen receptor; Cell therapy; Medicine; Process (computing); Clinical trial; Manufacturing process; T cell; Computer science; Immunology; Cell; Immune system; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005772479,0.0001667973,0.0003169194,0.000234103,0.0001421059,0.00002019762,0.0001715946,0.000103233,0.0007958518],"category_scores_gemma":[0.00003317621,0.0001161804,0.0001144878,0.001485889,0.0001752839,0.00007060284,0.00002143693,0.0001964666,0.00008403473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001092886,"about_ca_system_score_gemma":0.0001781831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001185861,"about_ca_topic_score_gemma":0.00000336607,"domain_scores_codex":[0.9984865,0.00006812809,0.0003058873,0.0003003982,0.0004741205,0.0003650024],"domain_scores_gemma":[0.998978,0.00006342818,0.0001242885,0.0005785445,0.0001785783,0.00007716787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006580075,0.00007900976,0.0006424465,0.00005286079,0.000152282,0.000004409863,0.001428777,0.000473951,0.9838206,0.000009445355,0.003119762,0.009558477],"study_design_scores_gemma":[0.001150421,0.0002660419,0.005917973,0.00006438473,0.00001882347,0.00002469344,0.0002362731,0.01573203,0.9679452,0.00002212917,0.008492778,0.0001292859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964858,0.0002795653,0.0001130229,0.0004981626,0.0005732017,0.00120546,0.000006873067,0.0004701856,0.0003677131],"genre_scores_gemma":[0.9864109,0.001906562,0.0009192829,0.0002024807,0.0006771049,0.00005109886,0.00005482255,0.0001194845,0.009658258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01587541,"threshold_uncertainty_score":0.8714019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07365111325701204,"score_gpt":0.3572147562017875,"score_spread":0.2835636429447754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}