{"id":"W4386574738","doi":"10.1016/j.jcyt.2023.07.012","title":"Automated production of gene-modified chimeric antigen receptor T cells using the Cocoon Platform","year":2023,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Octane (Canada)","funders":"National Cancer Institute; McMaster University","keywords":"Chimeric antigen receptor; Cell therapy; Medicine; Process (computing); Clinical trial; Manufacturing process; T cell; Computer science; Immunology; Cell; Immune system; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002783673,0.0005166686,0.0002576016,0.0003695335,0.0001806904,0.0005505618,0.0002951644,0.0003834595,0.001414972],"category_scores_gemma":[0.000334276,0.0001578573,0.0003763846,0.0003014923,0.0003024738,0.0002724506,0.0003858347,0.0005513976,0.0007998415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798871,"about_ca_system_score_gemma":0.0002802495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008346695,"about_ca_topic_score_gemma":0.0009052516,"domain_scores_codex":[0.9997311,0.00003883395,0.0000192763,0.00007650874,0.0000951671,0.00003901365],"domain_scores_gemma":[0.9998162,0.00004558637,0.00004681911,0.00003257541,0.00002903651,0.00002970693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006348499,0.00003753116,0.0001335664,0.0000420895,0.000003953454,0.0001386887,0.0000293484,0.0006666831,0.9923988,0.0003429286,0.0001648559,0.005978021],"study_design_scores_gemma":[0.00001703659,0.0002202184,0.0004398531,0.000006676486,0.00001122769,0.0001696263,0.00001364702,0.006434976,0.9874386,0.00006598995,0.00517322,0.00000886579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.635942,0.002163106,0.3479672,0.0002634522,0.0004025671,0.0006213152,0.0009148733,0.001975267,0.009750235],"genre_scores_gemma":[0.8669729,0.001153839,0.1267921,0.0001075232,0.00003421553,0.0002855236,0.0008366051,0.000207305,0.003610057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001414972,"threshold_uncertainty_score":0.004733622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07365111325701204,"score_gpt":0.3572147562017875,"score_spread":0.2835636429447754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}