{"id":"W4386575306","doi":"10.1016/s2468-1253(23)00205-4","title":"Serum anti-tissue transglutaminase IgA and prediction of duodenal villous atrophy in adults with suspected coeliac disease without IgA deficiency (Bi.A.CeD): a multicentre, prospective cohort study","year":2023,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Celiac Disease Research and Management","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Hospital Foundation","funders":"Università degli Studi di Salerno","keywords":"Villous atrophy; Tissue transglutaminase; Coeliac disease; Medicine; Gastroenterology; Internal medicine; Immunoglobulin A; Prospective cohort study; Atrophy; Cohort; Duodenum; Biopsy; Pathology; Disease; Immunology; Antibody; Immunoglobulin G; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004590069,0.0003742423,0.001109573,0.0004537576,0.0001409582,0.00001678928,0.000246815,0.00009586533,0.00005684679],"category_scores_gemma":[0.00005076857,0.0002772999,0.00008931756,0.000607137,0.000719022,0.00009011165,0.0001593986,0.0004784129,0.00001724506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000118435,"about_ca_system_score_gemma":0.0001393974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000438515,"about_ca_topic_score_gemma":0.004046768,"domain_scores_codex":[0.99635,0.0004981784,0.0005745773,0.0009122377,0.0005187848,0.001146194],"domain_scores_gemma":[0.9985209,0.00007580602,0.0001690391,0.0006671906,0.000180289,0.00038682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02429519,0.001655742,0.9693854,0.0003777308,0.0003697629,0.002051309,0.0008033084,0.00007011729,0.0002852953,0.00001920432,0.0002195462,0.0004673434],"study_design_scores_gemma":[0.01787359,0.005087291,0.9704204,0.000141931,0.0005444153,0.0001483645,0.001052622,0.004488359,0.00002884855,0.00002941242,0.00006249193,0.0001222375],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928021,0.0002641535,0.0001446608,0.001289083,0.0001181733,0.004871831,0.0002707806,0.0001644769,0.0000746697],"genre_scores_gemma":[0.9979346,0.0007500552,0.00004003123,0.0002505793,0.0001020269,0.0006833879,0.0001430484,0.00004411748,0.00005208954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006421605,"threshold_uncertainty_score":0.9999679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009577304213111123,"score_gpt":0.2611338468064573,"score_spread":0.2515565425933462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}