{"id":"W4386583813","doi":"10.1101/2023.09.09.556974","title":"NAD <sup>+</sup> depletion and altered mitochondrial function are key to the establishment of placental dysfunction in an inflammatory-driven subclass of preeclampsia","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"NAD+ kinase; Inflammation; Preeclampsia; Trophoblast; Oxidative stress; Placenta; Sirtuin 1; Mitochondrion; Biology; Oxidative phosphorylation; Internal medicine; Endocrinology; Immunology; Fetus; Medicine; Pregnancy; Biochemistry; Downregulation and upregulation; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000221402,0.0002457834,0.0002871274,0.0002298282,0.0001559083,0.0003185172,0.0002186144,0.0002889096,0.001151728],"category_scores_gemma":[0.0002163202,0.0001746547,0.0002021782,0.0001463873,0.0003230661,0.0001708172,0.000313507,0.0007225692,0.0001857996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002440378,"about_ca_system_score_gemma":0.0001703022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003503035,"about_ca_topic_score_gemma":0.0003448307,"domain_scores_codex":[0.9998802,0.00002514934,0.00001772919,0.00002737898,0.00002345728,0.00002606378],"domain_scores_gemma":[0.9998467,0.00001505547,0.00006124939,0.00002050025,0.0000146291,0.00004174114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001513041,0.0001049533,0.004311078,0.0001018184,0.00002046538,0.0008166185,0.00005664638,0.00005129584,0.9878787,0.0002568665,0.0001037903,0.004784633],"study_design_scores_gemma":[0.0001097812,0.002502737,0.1865748,0.00005665428,0.00009249585,0.008183089,0.0003658973,0.001407044,0.7942359,0.001041821,0.005413385,0.00001636572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871617,0.005387312,0.004910937,0.0004502091,0.0000570969,0.00005735159,0.0003024138,0.00009092571,0.001581983],"genre_scores_gemma":[0.9966977,0.001425259,0.0009016467,0.00006880049,0.00001436183,0.0000202099,0.0001686467,0.000005325287,0.0006980478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001151728,"threshold_uncertainty_score":0.003852963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02027405814044591,"score_gpt":0.2318895425119946,"score_spread":0.2116154843715487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}