{"id":"W4386591641","doi":"10.1002/jlcr.4062","title":"Preliminary PET imaging of [<sup>11</sup>C]evobrutinib in mouse models of colorectal cancer, SARS‐CoV‐2, and lung damage: Radiosynthesis via base‐aided palladium‐NiXantphos‐mediated <sup>11</sup>C‐carbonylation","year":2023,"lang":"en","type":"article","venue":"Journal of Labelled Compounds and Radiopharmaceuticals","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Azrieli Foundation; Canada Excellence Research Chairs, Government of Canada; Canada Foundation for Innovation","keywords":"Radiosynthesis; In vivo; Colorectal cancer; Positron emission tomography; Ex vivo; Cancer research; Chemistry; Bruton's tyrosine kinase; Lung cancer; Medicine; Imaging agent; Cancer; Nuclear medicine; Pathology; Tyrosine kinase; Internal medicine; Biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002515972,0.0004962451,0.001751109,0.001170709,0.0001483953,0.00005758832,0.0003613986,0.0002145217,0.00006210232],"category_scores_gemma":[0.0005274384,0.0004254542,0.000270985,0.001163239,0.0006559348,0.0004261314,0.0002640167,0.0007839567,0.00000195204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002023748,"about_ca_system_score_gemma":0.002174917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005455471,"about_ca_topic_score_gemma":0.00001811863,"domain_scores_codex":[0.9948708,0.0005392473,0.001943852,0.0005374769,0.001243377,0.0008651787],"domain_scores_gemma":[0.9956424,0.002180482,0.0007045658,0.0003646005,0.0005341367,0.0005737879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01469638,0.002474298,0.05695282,0.004549998,0.001902412,0.00437434,0.006786645,0.03679843,0.8647555,0.0001568817,0.003336227,0.003216066],"study_design_scores_gemma":[0.04100279,0.0004220328,0.001867165,0.0009777019,0.000602787,0.001381796,0.0005824887,0.8872878,0.06530691,0.0001226443,0.0001167341,0.0003291325],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883293,0.008864838,0.00009537263,0.001485607,0.00009847721,0.0008655393,0.00008639433,0.00004797418,0.0001265074],"genre_scores_gemma":[0.9883832,0.01027188,0.0007747331,0.0001507123,0.0001858875,0.00002480241,0.00002555211,0.00009350149,0.00008977807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8504894,"threshold_uncertainty_score":0.9998198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03331949472593893,"score_gpt":0.3356144561359858,"score_spread":0.3022949614100469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}