{"id":"W4386591641","doi":"10.1002/jlcr.4062","title":"Preliminary PET imaging of [<sup>11</sup>C]evobrutinib in mouse models of colorectal cancer, SARS‐CoV‐2, and lung damage: Radiosynthesis via base‐aided palladium‐NiXantphos‐mediated <sup>11</sup>C‐carbonylation","year":2023,"lang":"en","type":"article","venue":"Journal of Labelled Compounds and Radiopharmaceuticals","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Azrieli Foundation; Canada Excellence Research Chairs, Government of Canada; Canada Foundation for Innovation","keywords":"Radiosynthesis; In vivo; Colorectal cancer; Positron emission tomography; Ex vivo; Cancer research; Chemistry; Bruton's tyrosine kinase; Lung cancer; Medicine; Imaging agent; Cancer; Nuclear medicine; Pathology; Tyrosine kinase; Internal medicine; Biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002314067,0.0006270739,0.000264293,0.0003257313,0.0001503151,0.0002866406,0.0003105288,0.0006140998,0.001210164],"category_scores_gemma":[0.00008813383,0.0003294447,0.0002569391,0.0002005677,0.0002634572,0.0002273419,0.0001358599,0.0007685661,0.0003329304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003440123,"about_ca_system_score_gemma":0.0002389508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001329018,"about_ca_topic_score_gemma":0.00223138,"domain_scores_codex":[0.99989,0.00002243311,0.000005568598,0.00002836752,0.000022697,0.00003096114],"domain_scores_gemma":[0.9999374,0.00001087165,0.00001922424,0.000006294649,0.00001172085,0.00001454974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002319026,0.00002728981,0.00007766659,0.00005441843,0.000008839333,0.00007429993,0.00001730976,0.0002299191,0.9980412,0.0001075927,0.00010426,0.001025288],"study_design_scores_gemma":[0.00002636832,0.0006202104,0.0009739503,0.000006229374,0.00003150994,0.0003595315,0.00001846624,0.001004133,0.9940422,0.00003472955,0.00287457,0.00000800191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9488635,0.004054246,0.03520249,0.0002870472,0.00005802598,0.000350102,0.00195508,0.0005537118,0.008675844],"genre_scores_gemma":[0.9467918,0.003774473,0.03281831,0.0002980268,0.00002774792,0.0004770132,0.002672227,0.0001954578,0.01294492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329018,"threshold_uncertainty_score":0.004048347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03331949472593893,"score_gpt":0.3356144561359858,"score_spread":0.3022949614100469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}