{"id":"W4386591648","doi":"10.1097/ccm.0000000000006028","title":"Elevated Plasma Interleukin-18 Identifies High-Risk Acute Respiratory Distress Syndrome Patients not Distinguished by Prior Latent Class Analyses Using Traditional Inflammatory Cytokines: A Retrospective Analysis of Two Randomized Clinical Trials","year":2023,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Genentech; Swedish Orphan Biovitrum; China Scholarship Council; Research Councils UK; Intensive Care Society; National Institute of General Medical Sciences; Insmed; National Institute for Health and Care Research; Wellcome Trust; National Heart, Lung, and Blood Institute; National Institute for Social Care and Health Research; National Institutes of Health; Queen's University; Novavax; Gilead Sciences; Public Health Agency; GlaxoSmithKline; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; ARDS; Randomized controlled trial; Internal medicine; Hazard ratio; Lung; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02543604,0.0006886832,0.002219287,0.000816202,0.0005285109,0.002107881,0.0006469138,0.0009918715,0.001140562],"category_scores_gemma":[0.03231883,0.0005516915,0.004543832,0.001207535,0.001036412,0.001085783,0.0007969919,0.001125481,0.0001689898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006082446,"about_ca_system_score_gemma":0.0008453026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002439275,"about_ca_topic_score_gemma":0.0003827956,"domain_scores_codex":[0.9700469,0.01765099,0.005443742,0.00348703,0.002553634,0.0008176594],"domain_scores_gemma":[0.94007,0.02690493,0.02266316,0.005732653,0.00278801,0.001841251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1907204,0.0009358009,0.7375411,0.001942501,0.03828165,0.00019108,0.0002597178,0.0005208394,0.002234246,0.0004541803,0.0006061483,0.02631228],"study_design_scores_gemma":[0.04638166,0.02425259,0.8762691,0.0007149008,0.04197228,0.001047543,0.0002951841,0.002732058,0.001895196,0.0009167666,0.003387185,0.0001354781],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972494,0.02361385,0.001721728,0.0002498863,0.000104854,0.0006274059,0.0006111162,0.00001798178,0.0005591256],"genre_scores_gemma":[0.9969951,0.001300841,0.000742046,0.0001732128,0.00008221887,0.0002625389,0.0003749111,0.000006430735,0.00006269191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02543604,"threshold_uncertainty_score":0.1345203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07925623019083725,"score_gpt":0.4083166709283218,"score_spread":0.3290604407374845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}