{"id":"W4386592045","doi":"10.1001/jamaneurol.2023.2851","title":"Efficacy and Safety of Ravulizumab, a Complement C5 Inhibitor, in Adults With Amyotrophic Lateral Sclerosis","year":2023,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Amyotrophic lateral sclerosis; Medicine; Placebo; Interim analysis; Clinical endpoint; Internal medicine; Physical therapy; Adverse effect; Clinical trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004432286,0.0008159198,0.00126176,0.0002964671,0.0004213429,0.0006755746,0.0003895762,0.001720361,0.002182752],"category_scores_gemma":[0.004178812,0.0003476112,0.00106385,0.000271486,0.0007141485,0.0007768351,0.0003553817,0.001504606,0.0003479125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006374008,"about_ca_system_score_gemma":0.001066542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005557323,"about_ca_topic_score_gemma":0.0009355361,"domain_scores_codex":[0.9987269,0.0007522604,0.0001330348,0.0001412599,0.0001472078,0.00009939379],"domain_scores_gemma":[0.9981488,0.0005195751,0.000780774,0.00008587199,0.0001767179,0.000288241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8608208,0.009730953,0.01681125,0.001386886,0.001593513,0.0001247004,0.0002513589,0.0006606518,0.008056192,0.0001189841,0.001069935,0.09937458],"study_design_scores_gemma":[0.4741135,0.4445601,0.07225547,0.0002920779,0.002307511,0.0002590815,0.00009540552,0.0008782571,0.002866763,0.0002289666,0.002110851,0.00003215995],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860574,0.01051181,0.0003325995,0.0003998009,0.00009466194,0.0009450761,0.0003915558,0.00003081652,0.00123623],"genre_scores_gemma":[0.9957238,0.001743876,0.0006137636,0.0003780666,0.000137128,0.0007374352,0.0002469971,0.000003773177,0.0004150946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004432286,"threshold_uncertainty_score":0.02344048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02916181487922683,"score_gpt":0.2764903666567601,"score_spread":0.2473285517775333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}