{"id":"W4386592045","doi":"10.1001/jamaneurol.2023.2851","title":"Efficacy and Safety of Ravulizumab, a Complement C5 Inhibitor, in Adults With Amyotrophic Lateral Sclerosis","year":2023,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Amyotrophic lateral sclerosis; Medicine; Placebo; Interim analysis; Clinical endpoint; Internal medicine; Physical therapy; Adverse effect; Clinical trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002673235,0.0001924039,0.0005091598,0.0003531133,0.00005403694,0.00001393182,0.0001291053,0.0001856402,0.0001373513],"category_scores_gemma":[0.0001031706,0.0001460147,0.00004383445,0.0006705134,0.0003000722,0.00007438484,0.0002396376,0.0006182059,0.00004144307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003611869,"about_ca_system_score_gemma":0.00007286416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000381281,"about_ca_topic_score_gemma":0.0001428531,"domain_scores_codex":[0.9978979,0.0002131862,0.0004553592,0.0004761238,0.0003925993,0.0005647998],"domain_scores_gemma":[0.9990987,0.000209361,0.00009227714,0.0003322749,0.0000907783,0.0001765727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1119271,0.001032401,0.7402527,0.001000024,0.000241643,0.002125587,0.003362415,0.0004416554,0.0929061,0.0006726214,0.003184214,0.04285355],"study_design_scores_gemma":[0.01770018,0.003879539,0.9755377,0.0002883864,0.00001721104,0.00007361236,0.00001473543,0.001265976,0.0002940658,0.00003627996,0.0007781776,0.0001141125],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840691,0.00004682612,0.000003062409,0.01471938,0.00005988887,0.0008180353,0.0000165894,0.00007154368,0.0001955846],"genre_scores_gemma":[0.9982581,0.0004513048,0.00008003691,0.000898489,0.0001197327,0.0000501621,0.00004169695,0.00003652196,0.00006397862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.235285,"threshold_uncertainty_score":0.5954309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02916181487922683,"score_gpt":0.2764903666567601,"score_spread":0.2473285517775333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}