{"id":"W4386594135","doi":"10.1016/j.placenta.2023.07.068","title":"Melatonin induces PERK-ATF4 unfolded protein response and apoptosis in human placental choriocarcinoma cell line","year":2023,"lang":"en","type":"article","venue":"Placenta","topic":"Birth, Development, and Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec; Institut National de la Recherche Scientifique","funders":"","keywords":"Choriocarcinoma; Apoptosis; Unfolded protein response; Melatonin; Internal medicine; ATF4; Endocrinology; Cancer research; Cell biology; Chemistry; Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304321,0.0001785026,0.000262485,0.0003044943,0.0002902604,0.0002167171,0.0001764348,0.0001850362,0.002544684],"category_scores_gemma":[0.0001226853,0.0001287707,0.000320116,0.0004048956,0.0001506662,0.0001736276,0.0001536122,0.0005539757,0.0003461879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003549671,"about_ca_system_score_gemma":0.0003254411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003375502,"about_ca_topic_score_gemma":0.003299992,"domain_scores_codex":[0.999854,0.00001866711,0.00001901542,0.00002834132,0.00003597614,0.00004396339],"domain_scores_gemma":[0.9999284,0.00001794021,0.00001057391,0.00001541515,0.00001312759,0.0000145633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005825241,0.0001215496,0.0006562074,0.00008049046,0.0000165575,0.0003052116,0.000102339,0.00006349831,0.995961,0.0001615621,0.0003064863,0.001642732],"study_design_scores_gemma":[0.00008087476,0.000738611,0.01208493,0.00000781614,0.00004010248,0.0004877318,0.0001626266,0.0009742979,0.9790366,0.00007079186,0.006309024,0.000006522768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916373,0.002257798,0.001814039,0.000237161,0.0001081439,0.00004670976,0.001091749,0.0001177505,0.002689322],"genre_scores_gemma":[0.9884688,0.001174548,0.001487782,0.00009985393,0.00002171738,0.00007254932,0.002060934,0.00001473384,0.006599111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003375502,"threshold_uncertainty_score":0.008512795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03445191857918064,"score_gpt":0.2990164711798787,"score_spread":0.2645645526006981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}