{"id":"W4386602587","doi":"10.3390/microorganisms11092265","title":"Impact of Environmental Sub-Inhibitory Concentrations of Antibiotics, Heavy Metals, and Biocides on the Emergence of Tolerance and Effects on the Mutant Selection Window in E. coli","year":2023,"lang":"en","type":"article","venue":"Microorganisms","topic":"Pharmaceutical and Antibiotic Environmental Impacts","field":"Environmental Science","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"South African Medical Research Council; National Research Foundation","keywords":"Microbiology; Ampicillin; Biocide; Oxytetracycline; Benzalkonium chloride; Minimum inhibitory concentration; Biology; Population; Bacteria; Antibiotics; Chemistry; Genetics; Chromatography; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000248913,0.0001455185,0.0001910738,0.00003067153,0.00009167369,0.000007610219,0.0001067834,0.00004674118,0.0002072521],"category_scores_gemma":[0.00003555429,0.00008746507,0.00005061284,0.0002459003,0.0007090179,0.00006717519,0.00009432414,0.0001203969,0.00002174041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005163717,"about_ca_system_score_gemma":0.000007225447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001016314,"about_ca_topic_score_gemma":0.00001579067,"domain_scores_codex":[0.9990279,0.0001156114,0.0002400281,0.0002069984,0.0002011244,0.0002083471],"domain_scores_gemma":[0.9994438,0.0002483632,0.0001144466,0.0001318003,0.00000165216,0.00005997881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003299622,0.0001493395,0.09930032,0.00001624154,0.0000190141,0.000001682318,0.0002949888,0.0002084774,0.8994259,0.00005164995,0.0001048144,0.0003945797],"study_design_scores_gemma":[0.0001544669,0.0002143838,0.4344289,0.00003663442,0.00001049809,0.000002201134,0.00009642975,0.0001791739,0.5647737,0.0000495879,0.000004041656,0.00005000445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990665,0.00009410473,0.000006233841,0.0002912174,0.00004088018,0.0003696214,0.00006179488,0.000006811404,0.00006282524],"genre_scores_gemma":[0.9993536,0.0004598202,0.0000186933,0.0001291531,0.000009519676,5.267294e-7,0.000002883769,0.00001101435,0.00001474634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3351286,"threshold_uncertainty_score":0.3566722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267321621562022,"score_gpt":0.2470335810057003,"score_spread":0.2343603647900801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}