{"id":"W4386608462","doi":"10.1016/j.ccell.2023.08.003","title":"Peeling the I-Onion to Demystify Pseudoprogression","year":2023,"lang":"en","type":"letter","venue":"Cancer Cell","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Pembrolizumab; Medicine; Internal medicine; Cancer; Oncology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002474334,0.0003058412,0.0003611286,0.00008704664,0.0001627594,0.00005022431,0.000277177,0.000522331,0.0008109534],"category_scores_gemma":[0.00002443764,0.0001908031,0.0002485793,0.0003480561,0.00006874777,0.00002918731,0.00007946971,0.001096357,0.0003254208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005002905,"about_ca_system_score_gemma":0.0003902192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000842244,"about_ca_topic_score_gemma":0.00006788359,"domain_scores_codex":[0.9981912,0.00005413992,0.0003062304,0.0004812859,0.000501407,0.0004657586],"domain_scores_gemma":[0.998963,0.0001013704,0.0001404203,0.0005992946,0.00009461586,0.0001013201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002868702,0.00000920679,0.00009942932,0.0003402693,0.00008333749,0.0001321634,0.0002550218,0.000003984515,0.003926105,2.553334e-7,0.9734126,0.02145074],"study_design_scores_gemma":[0.0006439285,0.0001268816,0.0003223319,0.001063857,0.0001666965,0.00001680794,0.00007991093,0.00002163276,0.003912632,0.000007169309,0.9933901,0.0002480285],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002710039,0.01412094,0.00003039464,0.9742785,0.004088858,0.001060965,0.00006491815,0.0002117461,0.003433701],"genre_scores_gemma":[0.001302347,0.003962963,0.0001063275,0.9245711,0.01213494,0.000422309,0.0001868885,0.0001693388,0.0571438],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0537101,"threshold_uncertainty_score":0.8879371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03909476538941183,"score_gpt":0.3268921724169567,"score_spread":0.2877974070275449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}