{"id":"W4386623512","doi":"10.1111/bjh.19058","title":"Final report of <scp>TKI</scp> discontinuation trial with dasatinib for the second attempt of treatment‐free remission after failing the first attempt with imatinib: Treatment‐free Remission Accomplished by Dasatinib (<scp>TRAD</scp>) study","year":2023,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Toronto General Hospital; University of Alberta; London Health Sciences Centre; Hôpital de l'Enfant-Jésus; Université de Montréal; Hôpital Maisonneuve-Rosemont; Queen Elizabeth II Health Sciences Centre; Princess Margaret Cancer Centre; Vancouver General Hospital; University of Calgary; BC Cancer Agency; Alberta Health Services; McGill University Health Centre; University of Ottawa; CancerCare Manitoba; University Health Network; Ottawa Hospital; Dalhousie University; Western University; University of Toronto; University of British Columbia","funders":"Bristol-Myers Squibb Canada; Princess Margaret Cancer Foundation","keywords":"Dasatinib; Discontinuation; Medicine; Imatinib; Internal medicine; Tyrosine-kinase inhibitor; Drug holiday; Oncology; Immunology; Myeloid leukemia; Human immunodeficiency virus (HIV); Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001427992,0.0006383481,0.002169898,0.0002643308,0.0004446654,0.00009800494,0.0006858801,0.0002771901,0.00006618341],"category_scores_gemma":[0.002991255,0.0003628216,0.000509779,0.0005789639,0.0004342177,0.0003410706,0.0001591854,0.0004645521,0.000003092782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006191067,"about_ca_system_score_gemma":0.00117813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004450598,"about_ca_topic_score_gemma":0.001450692,"domain_scores_codex":[0.9947389,0.0003321815,0.002477486,0.0007463333,0.000991067,0.0007140083],"domain_scores_gemma":[0.9895161,0.004827657,0.003311345,0.001447786,0.0006447333,0.0002523963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.06193015,0.02025521,0.4429725,0.002775881,0.02247052,0.08279518,0.0531497,0.0004655847,0.006696509,0.00004412798,0.262628,0.04381657],"study_design_scores_gemma":[0.4963137,0.06943432,0.1050305,0.007633281,0.009546848,0.2145432,0.03999869,0.0009628028,0.0285725,0.0004809343,0.02692979,0.0005534217],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919352,0.001581331,0.0001765883,0.0009002399,0.0003487949,0.004473161,0.0002731597,0.00005855644,0.000252963],"genre_scores_gemma":[0.9938203,0.0002703011,0.0015043,0.00005574067,0.0003487342,0.0005446125,0.0002166956,0.0001334135,0.003105953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4343836,"threshold_uncertainty_score":0.9998824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03349169713017222,"score_gpt":0.2989456162039855,"score_spread":0.2654539190738133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}