{"id":"W4386623512","doi":"10.1111/bjh.19058","title":"Final report of <scp>TKI</scp> discontinuation trial with dasatinib for the second attempt of treatment‐free remission after failing the first attempt with imatinib: Treatment‐free Remission Accomplished by Dasatinib (<scp>TRAD</scp>) study","year":2023,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Toronto General Hospital; University of Alberta; London Health Sciences Centre; Hôpital de l'Enfant-Jésus; Université de Montréal; Hôpital Maisonneuve-Rosemont; Queen Elizabeth II Health Sciences Centre; Princess Margaret Cancer Centre; Vancouver General Hospital; University of Calgary; BC Cancer Agency; Alberta Health Services; McGill University Health Centre; University of Ottawa; CancerCare Manitoba; University Health Network; Ottawa Hospital; Dalhousie University; Western University; University of Toronto; University of British Columbia","funders":"Bristol-Myers Squibb Canada; Princess Margaret Cancer Foundation","keywords":"Dasatinib; Discontinuation; Medicine; Imatinib; Internal medicine; Tyrosine-kinase inhibitor; Drug holiday; Oncology; Immunology; Myeloid leukemia; Human immunodeficiency virus (HIV); Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004004412,0.0006848091,0.002188828,0.0002313884,0.0006138585,0.001601791,0.0007114866,0.001600473,0.003100497],"category_scores_gemma":[0.002594514,0.0002496911,0.002148677,0.0002625766,0.0003443177,0.0005619539,0.0003147061,0.002588139,0.0009094177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005552669,"about_ca_system_score_gemma":0.001252213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001122146,"about_ca_topic_score_gemma":0.002812371,"domain_scores_codex":[0.9987471,0.0006262364,0.0001023954,0.0001474423,0.0002228675,0.0001539443],"domain_scores_gemma":[0.9973425,0.0008245569,0.000404092,0.0002180811,0.0002978531,0.0009128718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6215351,0.01498906,0.05247747,0.002142887,0.009734082,0.002716783,0.0006790078,0.002912923,0.02103159,0.00182939,0.08389801,0.1860536],"study_design_scores_gemma":[0.5295265,0.2891272,0.1023506,0.0003028016,0.003878906,0.001368975,0.0001842286,0.002614317,0.004909557,0.001226686,0.06436745,0.000142617],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9161206,0.01033098,0.003115267,0.009144673,0.002578257,0.006265606,0.02292582,0.000335882,0.02918291],"genre_scores_gemma":[0.9567799,0.003537365,0.001885424,0.007185583,0.001178214,0.002788808,0.0145802,0.0001035556,0.01196091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004004412,"threshold_uncertainty_score":0.02117765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03349169713017222,"score_gpt":0.2989456162039855,"score_spread":0.2654539190738133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}