{"id":"W4386628771","doi":"10.2139/ssrn.4569069","title":"A Functional Screening Pipeline to Uncover Fungal Laccase-Like Multicopper Oxidases that Transform Industrial Lignins","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Enzyme-mediated dye degradation","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University; University of Toronto","funders":"","keywords":"Laccase; Multicopper oxidase; Chemistry; Pipeline (software); Lignin; Biochemistry; Organic chemistry; Computer science; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002042799,0.0005187663,0.0004817375,0.0001375116,0.0004763117,0.0003135459,0.0006007852,0.0007020762,0.0002653157],"category_scores_gemma":[0.0002473539,0.0002433026,0.0004490909,0.0005541692,0.00004656801,0.0002825705,0.0002573304,0.005286715,0.0001749125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008888177,"about_ca_system_score_gemma":0.0008529517,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000996881,"about_ca_topic_score_gemma":0.01999878,"domain_scores_codex":[0.9949315,0.0002107369,0.0006399641,0.0007165013,0.001023112,0.002478228],"domain_scores_gemma":[0.9986058,0.0003722391,0.0003452656,0.0001240206,0.0002135418,0.0003391744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004251126,0.001327896,0.03771795,0.00008248117,0.002240458,0.0002345938,0.000742614,0.01611737,0.07135986,0.002514774,0.136187,0.7272239],"study_design_scores_gemma":[0.02891368,0.01570508,0.2788645,0.005563783,0.004289707,0.005426368,0.03534652,0.008698009,0.03757517,0.2036953,0.3566132,0.01930873],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750397,0.00107458,0.004842615,0.01427227,0.002927217,0.0009754269,0.000384291,0.0003634731,0.0001204508],"genre_scores_gemma":[0.9871179,0.001067567,0.0001131162,0.0005970534,0.005160287,0.00006517513,0.0009797026,0.00001513361,0.004884003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7079152,"threshold_uncertainty_score":0.9978837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07902735100337507,"score_gpt":0.2532772859098961,"score_spread":0.174249934906521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}