{"id":"W4386628922","doi":"10.1101/2023.09.11.557219","title":"Dual inhibition of coronavirus M <sup>pro</sup> and PL <sup>pro</sup> enzymes by phenothiazines and their antiviral activity","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Saint Vincent University; Saint Mary's University; University of Saskatchewan; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Innovation Saskatchewan; Mitacs; Dalhousie Medical Research Foundation","keywords":"Proteases; Viral replication; Coronavirus; Protease; Biology; Vero cell; Chemistry; Virology; Biochemistry; Enzyme; Virus; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070739,0.0005160935,0.00031091,0.000185278,0.0000929939,0.000155786,0.000256565,0.0002733141,0.00327351],"category_scores_gemma":[0.00009079927,0.0001283263,0.0003528562,0.0001643488,0.0001038966,0.0001629698,0.0001642318,0.0004300845,0.0004126319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002038007,"about_ca_system_score_gemma":0.0001594655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003817067,"about_ca_topic_score_gemma":0.0008067906,"domain_scores_codex":[0.999933,0.00001161383,0.00000410609,0.00001150101,0.0000205548,0.00001936441],"domain_scores_gemma":[0.9999733,0.000004413052,0.00000938117,0.000001895465,0.000005268907,0.000005763048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007681522,0.0001625071,0.0003545542,0.001302924,0.000074397,0.0002076469,0.00002476824,0.002566044,0.9748611,0.0007764642,0.002370255,0.01653111],"study_design_scores_gemma":[0.0001465875,0.002042882,0.002393348,0.00004210067,0.00008640037,0.0003085108,0.00002362796,0.005830412,0.9766135,0.0002357516,0.01225858,0.000018423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9421816,0.03429998,0.008178621,0.001033448,0.000392676,0.000215858,0.003009573,0.0004805631,0.01020755],"genre_scores_gemma":[0.981539,0.009683921,0.003166279,0.00016954,0.00003653687,0.00008092627,0.001065868,0.00001695095,0.004240955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00327351,"threshold_uncertainty_score":0.01095098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04269676692507667,"score_gpt":0.2913314876760656,"score_spread":0.248634720750989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}