{"id":"W4386630159","doi":"10.1016/j.msard.2023.104998","title":"Are we there yet? The holy grail: A biomarker for Multiple Sclerosis","year":2023,"lang":"en","type":"editorial","venue":"Multiple Sclerosis and Related Disorders","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation","funders":"","keywords":"Holy Grail; Medicine; Multiple sclerosis; Biomarker; Immunology; World Wide Web; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02236839,0.006169314,0.01008895,0.00690292,0.004982667,0.0128474,0.006205193,0.0326828,0.006904397],"category_scores_gemma":[0.06239376,0.002763757,0.004726043,0.003108331,0.005071065,0.007651914,0.003088245,0.03327428,0.00733665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005161028,"about_ca_system_score_gemma":0.005575794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00392632,"about_ca_topic_score_gemma":0.008316812,"domain_scores_codex":[0.9881989,0.003942276,0.001943012,0.00113079,0.004267235,0.000517768],"domain_scores_gemma":[0.9354347,0.03836189,0.003413853,0.00151543,0.01553762,0.005736514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007885367,0.00001290499,0.00005099043,0.0005215902,0.0000786923,0.00009739422,0.00001865739,0.00001614671,0.00003054267,0.0002669682,0.9945479,0.004279486],"study_design_scores_gemma":[0.0005341089,0.0001489451,0.001067898,0.003026958,0.0008592601,0.0008163068,0.0001899459,0.0006242234,0.0002039536,0.004440812,0.987967,0.0001206287],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.00002608378,0.01249814,0.0001051771,0.0443626,0.9424618,0.00002178064,0.00005854278,0.00003594433,0.0004298739],"genre_scores_gemma":[0.0002765557,0.00591398,0.00009932683,0.03271935,0.9587746,0.00003632232,0.00002591525,0.00002169633,0.00213216],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.0326828,"threshold_uncertainty_score":0.1182967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08516344769704169,"score_gpt":0.3031964610574046,"score_spread":0.2180330133603629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}