{"id":"W4386630562","doi":"10.2337/db22-1033","title":"Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation","year":2023,"lang":"en","type":"article","venue":"Diabetes","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Toronto General Hospital; University of Toronto; University Health Network; Diabetes Canada; St. Michael's Hospital","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; J.P. Bickell Foundation; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Adipocyte; Internal medicine; Endocrinology; Insulin resistance; Adipose tissue; Biology; Inflammation; Glucose homeostasis; Caspase; Knockout mouse; Programmed cell death; Apoptosis; Insulin; Medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000192469,0.000473932,0.0002514482,0.0002625233,0.0001492138,0.0004501505,0.0002516871,0.0003853187,0.001975656],"category_scores_gemma":[0.0001230659,0.000127203,0.0002947952,0.0001713597,0.0003190865,0.0005387138,0.0004341309,0.0009654127,0.000327357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003372173,"about_ca_system_score_gemma":0.0001827605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001144519,"about_ca_topic_score_gemma":0.0001390953,"domain_scores_codex":[0.9997779,0.00002972727,0.00002111162,0.00006568963,0.00005459273,0.00005109463],"domain_scores_gemma":[0.9998878,0.000008502967,0.00003576836,0.00001003501,0.00002183529,0.00003609847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005275637,0.00004544031,0.0007711166,0.0001497893,0.00001415615,0.0002041921,0.000024908,0.00009144037,0.9890949,0.000629073,0.0001419738,0.008305446],"study_design_scores_gemma":[0.0001252306,0.0007570045,0.01695981,0.0000612201,0.00007375201,0.004189146,0.0001072417,0.001414681,0.9614729,0.00169002,0.01312866,0.00002034928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579253,0.0211224,0.01448773,0.001218345,0.0002156795,0.00004999731,0.0005459537,0.0002311676,0.004203442],"genre_scores_gemma":[0.9828022,0.007658969,0.004943823,0.0001745613,0.0000710533,0.00003668437,0.0003012314,0.00001973769,0.003991682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001975656,"threshold_uncertainty_score":0.006609201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004961315595031979,"score_gpt":0.207260942094314,"score_spread":0.202299626499282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}