{"id":"W4386636748","doi":"10.1016/j.stemcr.2023.08.003","title":"ISSCR standards for the use of human stem cells in basic research","year":2023,"lang":"en","type":"review","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stem Cell Network","funders":"European Research Council; Medical Research Council; Tohoku University; Ministry of Health and Welfare; Ministry of Science, ICT and Future Planning; Engineering Research Centers; Kanagawa Institute of Industrial Science and Technology; Nagoya City University; Wistar Institute; UK Regenerative Medicine Platform; University of Tokyo; Simons Foundation Autism Research Initiative; Simons Foundation; Burroughs Wellcome Fund; National Research Foundation of Korea; Massachusetts Department of Agricultural Resources; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta; Wisconsin Alumni Research Foundation; Francis Crick Institute; Wellcome Trust; Novo Nordisk Fonden; Cancer Research UK; Doris Duke Charitable Foundation","keywords":"Stem cell; Biology; Induced pluripotent stem cell; Biotechnology; Basic research; Risk analysis (engineering); Engineering ethics; Biochemical engineering; Data science; Computer science; Business; Library science; Cell biology; Embryonic stem cell; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006509683,0.0004654105,0.001317369,0.0004421919,0.0002214823,0.0001075522,0.0007136652,0.0006639851,0.00001736862],"category_scores_gemma":[0.00009680059,0.0003342794,0.0007258803,0.0007569608,0.0002598366,0.000006655249,0.0008049854,0.0006779839,0.00001541508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002246753,"about_ca_system_score_gemma":0.001773691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001230567,"about_ca_topic_score_gemma":0.0001598125,"domain_scores_codex":[0.9939865,0.0008019832,0.001644822,0.001185088,0.001447647,0.0009339354],"domain_scores_gemma":[0.9955541,0.000686111,0.0007489827,0.002116671,0.000740001,0.0001541062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001556826,0.0004783769,0.00009238553,0.1345989,0.000947715,0.001893149,0.0001840747,0.0001349506,0.02810501,0.00004500049,0.1695378,0.663827],"study_design_scores_gemma":[0.0001672014,0.0002795618,0.000001526253,0.003050533,0.0001100434,0.0000406633,0.00007063912,0.000006122276,0.01830093,0.00001002692,0.9776617,0.0003011056],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001156468,0.9923862,0.00004767071,0.00001220135,0.0004560634,0.004644718,0.0006750808,0.00001938999,0.0006021997],"genre_scores_gemma":[0.0005421487,0.9551542,0.00002546347,0.000004894265,0.0002090634,0.0007133681,0.0002840523,0.0001920955,0.0428747],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8081239,"threshold_uncertainty_score":0.999911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2202627926329815,"score_gpt":0.4251852203563631,"score_spread":0.2049224277233816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}