{"id":"W4386694446","doi":"10.1093/brain/awad309","title":"Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Alzheimer’s Research UK; NIHR Newcastle Biomedical Research Centre; Agence Nationale de la Recherche; National Institute for Health and Care Research; Alzheimer Society; Newcastle University; NIHR Oxford Biomedical Research Centre; Alzheimer's Society","keywords":"Frontotemporal lobar degeneration; Progressive supranuclear palsy; Tauopathy; Tau protein; Frontotemporal dementia; Microglia; Pathology; Neuroinflammation; Corticobasal degeneration; Neuroscience; Biology; Alzheimer's disease; Neurodegeneration; Medicine; Dementia; Immunology; Inflammation; Atrophy; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003334208,0.0004210743,0.0002341081,0.001442332,0.0004060632,0.0002398778,0.0001152979,0.0003391778,0.0009834124],"category_scores_gemma":[0.0002327081,0.000267389,0.000157749,0.0004647293,0.0005403352,0.0001824475,0.0002045635,0.0001992395,0.0002078116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002420634,"about_ca_system_score_gemma":0.0001304894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001772905,"about_ca_topic_score_gemma":0.002302563,"domain_scores_codex":[0.9998554,0.00002650414,0.00001569471,0.00003209105,0.00003436383,0.00003586824],"domain_scores_gemma":[0.9998975,0.00001741539,0.00002842644,0.000008583677,0.00002297648,0.00002509053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003971987,0.0004497163,0.286121,0.0003843351,0.000149467,0.01987886,0.002020917,0.0002149101,0.6745817,0.0002174488,0.0002571644,0.01175244],"study_design_scores_gemma":[0.00008392642,0.001295296,0.9480103,0.00003538683,0.00009953752,0.02576716,0.0008078534,0.0003760571,0.02190296,0.0002726217,0.001335446,0.00001356545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982585,0.0008011343,0.0001230738,0.00001038151,0.00000291178,0.00001076519,0.000038602,0.000008196079,0.0007464334],"genre_scores_gemma":[0.9985031,0.000565291,0.000261667,0.00002895143,0.0000119805,0.00001805938,0.00008891038,0.000002858902,0.0005192297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001772905,"threshold_uncertainty_score":0.003525138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02736701105790009,"score_gpt":0.2456126615776804,"score_spread":0.2182456505197803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}