{"id":"W4386694446","doi":"10.1093/brain/awad309","title":"Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Alzheimer’s Research UK; NIHR Newcastle Biomedical Research Centre; Agence Nationale de la Recherche; National Institute for Health and Care Research; Alzheimer Society; Newcastle University; NIHR Oxford Biomedical Research Centre; Alzheimer's Society","keywords":"Frontotemporal lobar degeneration; Progressive supranuclear palsy; Tauopathy; Tau protein; Frontotemporal dementia; Microglia; Pathology; Neuroinflammation; Corticobasal degeneration; Neuroscience; Biology; Alzheimer's disease; Neurodegeneration; Medicine; Dementia; Immunology; Inflammation; Atrophy; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002590759,0.0001119133,0.0001070297,0.0001651171,0.0001078601,0.00006325014,0.00006206161,0.00006063192,0.00001922856],"category_scores_gemma":[0.0002202288,0.0001052585,0.00001386596,0.0003545104,0.00004130564,0.0003309204,0.00002722965,0.0001153828,0.00006437785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001798766,"about_ca_system_score_gemma":0.00004611227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001091164,"about_ca_topic_score_gemma":0.0002793274,"domain_scores_codex":[0.9987696,0.0003038313,0.0001809023,0.0003869053,0.0001823654,0.0001763617],"domain_scores_gemma":[0.999575,0.0001282174,0.0000794327,0.000149547,0.00001499739,0.0000528347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004249762,0.0000222652,0.0005321403,0.000005699642,1.500919e-7,0.000091931,0.0002119967,0.0003476503,0.9937729,0.003331589,0.0007201586,0.000921086],"study_design_scores_gemma":[0.0007452917,0.0001390836,0.006878549,0.000003737107,0.000001428868,0.00003730055,0.0000247208,0.007543942,0.9831874,0.0004858546,0.0008279368,0.0001247035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949883,0.00000237727,0.001789354,0.001985373,0.0001606106,0.0002718122,0.000009626314,0.000154006,0.0006385749],"genre_scores_gemma":[0.9976711,0.00001459733,0.0002543482,0.001133087,0.00007247338,0.00002848843,0.00001922032,0.00001572552,0.0007909331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01058538,"threshold_uncertainty_score":0.4292316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02736701105790009,"score_gpt":0.2456126615776804,"score_spread":0.2182456505197803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}