{"id":"W4386703138","doi":"10.1101/2023.09.12.557383","title":"Mouse models for pancreatic ductal adenocarcinoma are affected by the cre-driver used to promote KRAS <sup>G12D</sup> activation","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Children’s Health Research Institute; Lawson Health Research Institute; Ontario Institute for Cancer Research","funders":"Mitacs; Canadian Institutes of Health Research; Cancer Research Society","keywords":"KRAS; Cre recombinase; Haploinsufficiency; Cancer research; Pancreatic Intraepithelial Neoplasia; Pancreatic cancer; Biology; Acinar cell; Carcinogenesis; Pancreas; Tamoxifen; Genetically modified mouse; Pancreatic tumor; Transgene; Cancer; Gene; Mutation; Endocrinology; Phenotype; Genetics; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006994588,0.00138994,0.0007752694,0.002486027,0.0006308093,0.000906618,0.0007485674,0.001622246,0.005196924],"category_scores_gemma":[0.000277913,0.0008501066,0.0011477,0.001083928,0.0008748877,0.0006770794,0.000683674,0.00263911,0.002055668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006485762,"about_ca_system_score_gemma":0.0004139072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006386717,"about_ca_topic_score_gemma":0.001554665,"domain_scores_codex":[0.9986349,0.0001756735,0.000282481,0.0003240298,0.0003714162,0.0002115126],"domain_scores_gemma":[0.9990259,0.0001255456,0.0003919179,0.0001564162,0.0000761127,0.0002240476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002255376,0.0001314902,0.0003465911,0.00006333092,0.00001649053,0.0001758475,0.00004415266,0.00004495215,0.9975973,0.0002656899,0.0001159076,0.0009726527],"study_design_scores_gemma":[0.00007426007,0.0006701727,0.00398293,0.00003359434,0.00006640892,0.001432552,0.00008813641,0.0005072483,0.9849128,0.0001057806,0.008107185,0.00001899275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542935,0.002698118,0.02710835,0.0007336753,0.0002968933,0.0007281497,0.007361806,0.001398765,0.005380739],"genre_scores_gemma":[0.9050214,0.004296508,0.04214098,0.0005280919,0.00005559708,0.001742962,0.01029558,0.0009537794,0.03496519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005196924,"threshold_uncertainty_score":0.01738548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05033918984511485,"score_gpt":0.2893836017186552,"score_spread":0.2390444118735404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}