{"id":"W4386705079","doi":"10.2139/ssrn.4569728","title":"A Targeted Amino Acid Mutation in Influenza a Virus Universal Epitope Transforms Immunogenicity and Protective Immunity via CD4 T Cell Activation","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Immunogenicity; Epitope; Virology; Mutation; Immunity; Virus; Influenza A virus; Biology; Immunology; Immune system; Gene; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092121,0.000191948,0.0001587713,0.0001396722,0.00007801285,0.0001690753,0.0001591597,0.0002487139,0.002807534],"category_scores_gemma":[0.0001300436,0.00008434713,0.0001717907,0.00007992832,0.0001882318,0.0001378614,0.000166223,0.0004373125,0.0005150474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000131917,"about_ca_system_score_gemma":0.0001015283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001405935,"about_ca_topic_score_gemma":0.00009211705,"domain_scores_codex":[0.9999272,0.00001722748,0.000005275064,0.00001435244,0.0000112058,0.00002477248],"domain_scores_gemma":[0.9999434,0.00001783158,0.00001049537,0.000009995775,0.000004657204,0.0000136102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003643789,0.00005756409,0.0001582248,0.00001228,0.000004916081,0.00005299817,0.0000078387,0.0001016787,0.9971809,0.0002346921,0.0000520591,0.001772564],"study_design_scores_gemma":[0.00009415106,0.0008365066,0.003818572,0.000004751054,0.00002633851,0.0004352725,0.00003592844,0.002073895,0.9905719,0.0005240028,0.001574044,0.000004746969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969648,0.0002042817,0.0009103187,0.00007135987,0.00003739687,0.00001006176,0.00006178326,0.0000426668,0.001697323],"genre_scores_gemma":[0.9980487,0.000101191,0.0004116308,0.0000400489,0.00001070024,0.000006762191,0.00008216576,0.00001113409,0.001287704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002807534,"threshold_uncertainty_score":0.009392142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03583432356027989,"score_gpt":0.320349339707039,"score_spread":0.2845150161467591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}