{"id":"W4386708524","doi":"10.1016/j.chom.2023.08.012","title":"An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status","year":2023,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"U.S. Military HIV Research Program; National Institute of Allergy and Infectious Diseases; National Institute of Mental Health; U.S. Department of Defense; Gilead Sciences; Chulalongkorn University; ViiV Healthcare; Henry M. Jackson Foundation; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Provirus; Biology; CD8; Cytotoxic T cell; Immunology; Human immunodeficiency virus (HIV); Cell; Cell biology; Virology; Genetics; Immune system; Gene; Genome; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002114299,0.0001391594,0.0003283907,0.0003714984,0.0002881816,0.0007519464,0.0001934111,0.0003390491,0.002886697],"category_scores_gemma":[0.0006380089,0.0001515879,0.0001476296,0.0001999086,0.0002259207,0.0004181117,0.0003176235,0.0007349026,0.0004198093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001975036,"about_ca_system_score_gemma":0.0002398551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004086882,"about_ca_topic_score_gemma":0.0003735915,"domain_scores_codex":[0.9998544,0.00002226778,0.00001282156,0.00002972167,0.00002692873,0.00005375979],"domain_scores_gemma":[0.9994761,0.0001345859,0.000136433,0.00006272241,0.00006929706,0.0001208708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007147816,0.0003879529,0.1073241,0.0001866453,0.00006453649,0.0006997291,0.0004054449,0.0002324711,0.8494911,0.000462734,0.0003384445,0.03325896],"study_design_scores_gemma":[0.00004573555,0.001722468,0.8718465,0.00004845203,0.0001201436,0.002597295,0.0005035111,0.001502981,0.1180606,0.0006639353,0.002860605,0.0000277328],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967936,0.001194192,0.0004603782,0.00004150674,0.00001463929,0.00001889878,0.0002210129,0.00003759023,0.001218208],"genre_scores_gemma":[0.9984679,0.0001713193,0.000173722,0.00002018021,0.00001735103,0.00001698382,0.0002082725,0.000006838277,0.0009175015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002886697,"threshold_uncertainty_score":0.009656906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388642339522764,"score_gpt":0.2371927023735977,"score_spread":0.22330627897837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}