{"id":"W4386709864","doi":"10.1038/s41467-023-41427-y","title":"Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; Ferring Research Institute; Government of Canada; National Institutes of Health; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada","keywords":"In vivo; Human serum albumin; Albumin; Peptide; Chemistry; Cysteine; Biochemistry; Apelin; Serum albumin; Plasma protein binding; Biology; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000506437,0.0001140878,0.0002358689,0.0004678748,0.0000861693,0.00002068305,0.00042625,0.000362913,0.00003725859],"category_scores_gemma":[0.001011536,0.00009968768,0.0000524012,0.001153556,0.0002909985,0.00008408009,0.0005366745,0.0008890773,0.0000285991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007781407,"about_ca_system_score_gemma":0.0001402792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004536096,"about_ca_topic_score_gemma":0.000219731,"domain_scores_codex":[0.9985768,0.0001199807,0.0003327481,0.0002446648,0.0004794265,0.0002464202],"domain_scores_gemma":[0.9979367,0.0006057391,0.00005697915,0.001107671,0.0001254746,0.0001674104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001739169,0.0003689369,0.04604353,0.00009684185,0.00006701087,0.00001916093,0.0009970366,0.00002059738,0.9289721,0.002236766,0.001984767,0.01901931],"study_design_scores_gemma":[0.001022982,0.0001042934,0.9697132,0.0002681368,0.00004469189,0.00001524648,0.0004306038,0.007031881,0.01774532,0.0006128871,0.00286295,0.0001478222],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795029,0.002776094,0.00008286109,0.01584144,0.00003334474,0.0005874345,0.00003936063,0.00005066809,0.001085952],"genre_scores_gemma":[0.9948015,0.00188005,0.002465924,0.0002870678,0.00002129554,0.00004485407,0.00009869544,0.00002060849,0.000380012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9236696,"threshold_uncertainty_score":0.4065146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03802760082587335,"score_gpt":0.3636135469394127,"score_spread":0.3255859461135393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}