{"id":"W4386725613","doi":"10.1152/japplphysiol.00537.2023","title":"Brief ambient cooling preserves autophagy in peripheral blood mononuclear cells from older adults during 9 h of heat exposure","year":2023,"lang":"en","type":"article","venue":"Journal of Applied Physiology","topic":"Thermoregulation and physiological responses","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Calgary; University of Ottawa","funders":"Canadian Institutes of Health Research; Health Canada; Government of Canada","keywords":"Peripheral blood mononuclear cell; Medicine; Autophagy; Heat shock; Heat shock protein; Inflammation; Immunosenescence; Apoptosis; Internal medicine; Heart rate; Ageing; Heat stress; Immunology; Endocrinology; Andrology; Blood pressure; Chemistry; Biology; Animal science; In vitro; Biochemistry; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002161787,0.0002041081,0.0004971554,0.0001281569,0.0003296492,0.0003052799,0.0001386076,0.000271726,0.002503675],"category_scores_gemma":[0.0002728072,0.0001109484,0.0003661774,0.000106302,0.0002036074,0.0002344548,0.0002402749,0.0005200008,0.0003847679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001258988,"about_ca_system_score_gemma":0.0003317613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006650023,"about_ca_topic_score_gemma":0.001740133,"domain_scores_codex":[0.9998474,0.00003002664,0.00001493269,0.00003795991,0.00001707214,0.00005259071],"domain_scores_gemma":[0.9999206,0.00001096839,0.00001345021,0.00001209705,0.00001825473,0.00002467393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02411853,0.0007675502,0.01223978,0.0006403283,0.0001427963,0.0003005231,0.0006354862,0.0003145766,0.9393669,0.0001173412,0.001738514,0.01961767],"study_design_scores_gemma":[0.001272147,0.01735209,0.5831254,0.000302658,0.0006329007,0.0008709145,0.001739637,0.002277812,0.377936,0.0008080906,0.01358309,0.0000993107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949523,0.002673555,0.0006020615,0.0001787602,0.000149229,0.00003380334,0.0006607029,0.00002190966,0.0007276268],"genre_scores_gemma":[0.996972,0.0006631963,0.0003642826,0.0002586066,0.000069972,0.0001086575,0.000643562,0.000008001086,0.0009116976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002503675,"threshold_uncertainty_score":0.008375585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011454206906417,"score_gpt":0.2430272640022161,"score_spread":0.2329127219331519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}