{"id":"W4386725741","doi":"10.1083/jcb.202302112","title":"Fusion pore dynamics of large secretory vesicles define a distinct mechanism of exocytosis","year":2023,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE European Research Council; Israel Science Foundation; University of Toronto; Philipps-Universität Marburg; Minerva Foundation; European Commission","keywords":"Exocytosis; Cell biology; Myosin; Secretory Vesicle; Amphiphysin; Vesicle; Biophysics; Actin; PDZ domain; Vesicle fusion; Secretion; Fusion; Lipid bilayer fusion; Chemistry; Biology; Membrane; Biochemistry; Dynamin; Cell; Endocytosis; Synaptic vesicle","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001749813,0.0002001317,0.0002285546,0.0002656332,0.0001851468,0.0006174919,0.0001808369,0.0003975212,0.000383012],"category_scores_gemma":[0.000228042,0.0001333418,0.0003111808,0.0001539166,0.0003867928,0.0007995516,0.0004067716,0.0003732163,0.0001874348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003855816,"about_ca_system_score_gemma":0.0001208797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001407633,"about_ca_topic_score_gemma":0.0001482565,"domain_scores_codex":[0.9998605,0.00001559018,0.00001255512,0.00003354662,0.00005425063,0.00002359575],"domain_scores_gemma":[0.9998825,0.00002393565,0.00002909351,0.000013488,0.00001900867,0.00003204123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003935675,0.000004023276,0.0004566012,0.00001758896,0.000003557911,0.00008602776,0.00002364854,0.0001670007,0.9971909,0.0008159443,0.00001614083,0.001179244],"study_design_scores_gemma":[0.00002008371,0.0001632228,0.02896159,0.00001123885,0.00001326589,0.001777544,0.0001280761,0.008590749,0.956612,0.001466574,0.002231486,0.00002423796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848508,0.00127272,0.01269162,0.00006692644,0.00001176264,0.00001341374,0.0001172995,0.0001394183,0.000836173],"genre_scores_gemma":[0.9965782,0.0003013181,0.002698138,0.00001163253,0.00000459762,0.000006186249,0.00006956804,0.00001096934,0.0003193633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006174919,"threshold_uncertainty_score":0.002797604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00920007110591336,"score_gpt":0.2256764981130992,"score_spread":0.2164764270071858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}