{"id":"W4386726424","doi":"10.1080/19336896.2023.2256928","title":"Serial changes in regional cerebral blood flow in Gerstmann–Sträussler–Scheinker disease caused by a Pro-to-Leu mutation at codon 105 in the prion protein gene","year":2023,"lang":"en","type":"article","venue":"Prion","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Tokyo Medical and Dental University; Ministry of Health, British Columbia","keywords":"Cerebral blood flow; Frontal lobe; Hyperintensity; Magnetic resonance imaging; Atrophy; Medicine; White matter; Pathology; Cardiology; Radiology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005157308,0.0002033845,0.0001537813,0.0001599755,0.00007725228,0.0000424665,0.0002260519,0.0001372401,0.00001954324],"category_scores_gemma":[0.0001625127,0.0001808649,0.00006291458,0.0004370125,0.00003187177,0.00001374685,0.0001681312,0.0001361318,0.00002149324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007207203,"about_ca_system_score_gemma":0.0001005061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001054541,"about_ca_topic_score_gemma":0.001380837,"domain_scores_codex":[0.9982836,0.0002481523,0.0002669938,0.0005225973,0.0002782272,0.0004004279],"domain_scores_gemma":[0.9994387,0.00001700279,0.00008684299,0.0003046859,0.00003164984,0.0001211337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001383658,0.0002694388,0.01381972,0.0001150407,0.00001963942,0.00008923566,0.0008425604,0.0008135528,0.9656584,0.00002057572,0.001490119,0.01547812],"study_design_scores_gemma":[0.01181861,0.001053663,0.3701092,0.0006520389,0.00008282078,0.00001953021,0.0004777949,0.007810983,0.5651367,0.0007469744,0.04054061,0.001551118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933755,0.001756316,0.00003320577,0.0029547,0.0000691928,0.001715577,0.0000601748,0.00002564937,0.000009649692],"genre_scores_gemma":[0.9964947,0.000609377,0.0001641854,0.0004530181,0.0002055466,0.0007979823,0.001148629,0.00003162454,0.00009494364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4005217,"threshold_uncertainty_score":0.7375458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167750331351241,"score_gpt":0.2511633157254423,"score_spread":0.2343882825903182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}