{"id":"W4386728941","doi":"10.1097/hc9.0000000000000264","title":"Validation and optimization of AFP-based biomarker panels for early HCC detection in Latin America and Europe","year":2023,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Fujirebio Europe","keywords":"Medicine; Internal medicine; Cirrhosis; Stage (stratigraphy); Cohort; Biomarker; Gastroenterology; Hepatocellular carcinoma; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01227507,0.0007074013,0.0004865199,0.001654951,0.0002891647,0.001184284,0.0004379638,0.0004571808,0.0004956989],"category_scores_gemma":[0.01022466,0.0001825575,0.0005312526,0.001388706,0.0006358,0.0003498698,0.001177263,0.0002850661,0.0002248833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000893286,"about_ca_system_score_gemma":0.001036331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006187,"about_ca_topic_score_gemma":0.003949432,"domain_scores_codex":[0.9962063,0.002294851,0.000423816,0.0004217784,0.0004402746,0.0002129841],"domain_scores_gemma":[0.9964901,0.000928623,0.0007863321,0.0002961393,0.001338665,0.0001602176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001040923,0.0001415381,0.9552551,0.0000950214,0.0002300741,0.0001430371,0.000412058,0.00149722,0.005290963,0.0002694273,0.0005862359,0.03503836],"study_design_scores_gemma":[0.0003669772,0.001046117,0.9649766,0.000288136,0.0003955282,0.0009947012,0.001126701,0.006423426,0.01228143,0.0006055823,0.01145622,0.00003865308],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865257,0.002667372,0.00518616,0.0004186626,0.00004962847,0.0001755746,0.0008565709,0.00007387226,0.004046627],"genre_scores_gemma":[0.9915562,0.0006143805,0.005542163,0.0004051635,0.0000260616,0.0001601697,0.001353716,0.0000185961,0.0003236517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01227507,"threshold_uncertainty_score":0.06491756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1298599287261483,"score_gpt":0.3078575980726596,"score_spread":0.1779976693465113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}