{"id":"W4386741569","doi":"10.1101/2023.09.12.556363","title":"B Cells Promote T Cell Immunosenescence and Mammalian Aging Parameters","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Alberta; Discovery Centre; Princess Margaret Cancer Centre; University Health Network; Toronto General Hospital; University of Toronto; Ted Rogers Centre for Heart Research","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Immunosenescence; Naive T cell; Biology; Immune system; T cell; Cell; Immunology; Acquired immune system; B cell; Insulin receptor; Receptor; B-cell receptor; Cell biology; T-cell receptor; Antibody; Insulin; Genetics; Endocrinology; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002724695,0.0004097286,0.0002577512,0.0003925422,0.000160237,0.000519898,0.0001116747,0.0004296123,0.002460108],"category_scores_gemma":[0.0001575752,0.0001413743,0.0002478883,0.0001795588,0.0002292342,0.0002762456,0.0003767428,0.0008297877,0.001326869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001810811,"about_ca_system_score_gemma":0.0001425117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000201137,"about_ca_topic_score_gemma":0.000222029,"domain_scores_codex":[0.9998627,0.00002294074,0.000007136694,0.00003246233,0.00005028928,0.00002446231],"domain_scores_gemma":[0.9999022,0.000009447936,0.00002631366,0.00001393922,0.00002019248,0.00002783691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001196291,0.00002330019,0.0005058862,0.00006032213,0.000008317648,0.0000626098,0.00002348022,0.00007615344,0.9923734,0.0006036227,0.000359107,0.005784213],"study_design_scores_gemma":[0.00003362601,0.0002391917,0.01513398,0.00002496646,0.00002537447,0.0005048582,0.00005456489,0.001152199,0.9606332,0.001189184,0.02100054,0.000008281462],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.924669,0.02150296,0.03221799,0.001521341,0.0006097084,0.00006690225,0.001417517,0.001165947,0.01682873],"genre_scores_gemma":[0.9663587,0.005489296,0.009896482,0.0004949555,0.0001727073,0.00005538285,0.001006301,0.0001907656,0.01633542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002460108,"threshold_uncertainty_score":0.008229911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458873404565125,"score_gpt":0.2064961160292288,"score_spread":0.1919073819835775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}