{"id":"W4386742095","doi":"10.1101/2023.09.13.557610","title":"Defining the SPCA2C interactome identifies unique links to Store-Operated Ca <sup>2+</sup> Entry","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Children's Health Foundation","keywords":"Interactome; STIM1; Cell biology; Endoplasmic reticulum; Biology; Syntaxin; ORAI1; C2 domain; Calcium signaling; Calmodulin; Subcellular localization; Signal transduction; Biochemistry; Exocytosis; Secretion; Cytoplasm; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491374,0.0003918157,0.0004231772,0.001039501,0.0004251996,0.0004891318,0.0001816145,0.0004404127,0.00303097],"category_scores_gemma":[0.0002850289,0.0001336413,0.0005247251,0.0008972705,0.0001420253,0.0002518079,0.0003752291,0.0003377697,0.0008027633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000380504,"about_ca_system_score_gemma":0.0002430423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121402,"about_ca_topic_score_gemma":0.001684475,"domain_scores_codex":[0.9998006,0.0000163476,0.00001178329,0.0000703777,0.0000686837,0.00003216433],"domain_scores_gemma":[0.999838,0.00002788917,0.00004876018,0.00001171317,0.00003789343,0.00003566888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006575753,0.00003866532,0.02648145,0.0003739822,0.0001360032,0.0005653097,0.00005523944,0.0006246118,0.9631525,0.0004158382,0.001342817,0.006156088],"study_design_scores_gemma":[0.00008251837,0.0003051963,0.5035731,0.0001074261,0.0004252568,0.005483573,0.0003541035,0.04344519,0.4169028,0.001463628,0.02779347,0.00006377901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830393,0.00275334,0.005388545,0.0002162782,0.00002611256,0.00003096824,0.006563245,0.0002076681,0.001774405],"genre_scores_gemma":[0.9793715,0.0007756088,0.006138436,0.0001598473,0.00001973657,0.00005709077,0.01202701,0.00003654112,0.001414297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00303097,"threshold_uncertainty_score":0.01013958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02371243420756107,"score_gpt":0.2538800656094286,"score_spread":0.2301676314018675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}