{"id":"W4386742984","doi":"10.1136/bmjopen-2022-070027","title":"Impact of a Powdered Meal Replacement on Metabolism and Gut Microbiota (PREMIUM) in individuals with excessive body weight: a study protocol for a randomised controlled trial","year":2023,"lang":"en","type":"article","venue":"BMJ Open","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Mitacs","keywords":"Medicine; Appetite; Microbiome; Weight management; Gut flora; Weight loss; Randomized controlled trial; Systemic inflammation; Meal; Clinical trial; Physiology; Internal medicine; Obesity; Inflammation; Immunology; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03440617,0.006771322,0.01446227,0.002706215,0.003359951,0.005150763,0.004113223,0.01084759,0.06243997],"category_scores_gemma":[0.03108046,0.003200085,0.007059131,0.003472495,0.004620066,0.004558441,0.002301369,0.007152487,0.01329447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005024505,"about_ca_system_score_gemma":0.01471666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00258422,"about_ca_topic_score_gemma":0.005102894,"domain_scores_codex":[0.9788445,0.01243125,0.002230543,0.001898942,0.002138709,0.002455967],"domain_scores_gemma":[0.9853142,0.004137393,0.00310895,0.002000838,0.003112454,0.002326139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9496089,0.009581191,0.0004493518,0.013554,0.001445516,0.0002195468,0.0003076415,0.001022054,0.001634462,0.002249791,0.00635713,0.01357059],"study_design_scores_gemma":[0.9639677,0.02112061,0.0009708329,0.001763407,0.0005718927,0.00003144578,0.00007612516,0.0009473944,0.0003057137,0.001182972,0.008995106,0.00006675094],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.001825519,0.0002502837,0.0007194646,0.0001495496,0.0003069695,0.9957975,0.0004540276,0.00006581259,0.0004309723],"genre_scores_gemma":[0.001912464,0.0001212448,0.001176184,0.000147147,0.00006026888,0.9961596,0.00007395024,0.000004557131,0.0003446961],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.06243997,"threshold_uncertainty_score":0.2088825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04574713320411793,"score_gpt":0.4346271011388732,"score_spread":0.3888799679347552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}