{"id":"W4386744071","doi":"10.7554/elife.87038.3.sa4","title":"Author Response: A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Protein subunit; Extracellular; Interface (matter); Channel (broadcasting); Chemistry; Biophysics; Molecule; Biology; Biochemistry; Computer science; Computer network; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002280414,0.0004539051,0.0006194557,0.0003794907,0.001045443,0.001730633,0.0007488746,0.004927638,0.1684048],"category_scores_gemma":[0.01383761,0.0002516778,0.00048697,0.0002763945,0.001088164,0.00103858,0.001328601,0.003428926,0.04615366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001148247,"about_ca_system_score_gemma":0.002057402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001084207,"about_ca_topic_score_gemma":0.002692552,"domain_scores_codex":[0.9980277,0.000457387,0.0001476467,0.0002402593,0.0008257034,0.0003012394],"domain_scores_gemma":[0.9919026,0.002574716,0.0004821873,0.0003652302,0.003443175,0.0012321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003757534,0.00001979975,0.0002668375,0.0003212042,0.00001671098,0.0003668925,0.00009181089,0.0001142397,0.003447727,0.002711408,0.9735174,0.01875023],"study_design_scores_gemma":[0.0001335618,0.00008558568,0.0009765186,0.0001087126,0.00001333037,0.0004659494,0.0003780547,0.0002813753,0.004495316,0.002199427,0.9908317,0.00003050444],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.008608347,0.006084251,0.007010681,0.7153562,0.1836715,0.00041889,0.002449143,0.001563935,0.07483703],"genre_scores_gemma":[0.080712,0.006722715,0.00609221,0.2586836,0.03364252,0.0002952482,0.002323707,0.0007577645,0.6107702],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1684048,"threshold_uncertainty_score":0.5633702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06889209572753754,"score_gpt":0.346485317401354,"score_spread":0.2775932216738164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}