{"id":"W4386744611","doi":"10.1101/2023.09.13.557392","title":"Adopting orphan receptors: group IX/X transition metals as potential ligands of zebrafish Tlr4 homologs","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta; Cancer Research Institute","keywords":"Zebrafish; TLR4; Biology; Gene knockdown; Homologous chromosome; Receptor; Function (biology); Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001561126,0.0003041014,0.0001678051,0.0002193866,0.0002120521,0.0002892816,0.0002128214,0.0004911424,0.004310181],"category_scores_gemma":[0.0001305467,0.0001776101,0.0003037317,0.00009911057,0.0003494603,0.0002672784,0.0005369689,0.0006286126,0.001011594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004313635,"about_ca_system_score_gemma":0.0002691818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001218273,"about_ca_topic_score_gemma":0.001673629,"domain_scores_codex":[0.9998674,0.00001259241,0.000007022112,0.00003750453,0.00004438644,0.00003101878],"domain_scores_gemma":[0.9999423,0.000005094292,0.00002254568,0.000006826876,0.00001049821,0.00001275987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005311423,0.000003850133,0.0002936615,0.000030066,0.000002839281,0.00006708482,0.000009994632,0.00007064235,0.9980447,0.0002425976,0.0001228273,0.001058594],"study_design_scores_gemma":[0.00002888003,0.0001891202,0.006548244,0.00002205941,0.00002306006,0.000472587,0.0001044353,0.001396352,0.9808564,0.0003481711,0.009997918,0.00001283393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9572495,0.002856785,0.02667175,0.001496755,0.0002921422,0.00009104116,0.001231883,0.0004961754,0.009614011],"genre_scores_gemma":[0.9727458,0.0009192156,0.009412045,0.0003108028,0.00002444949,0.00007517255,0.0006366006,0.00006108898,0.01581481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004310181,"threshold_uncertainty_score":0.01441902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01160625319728483,"score_gpt":0.2142583256907567,"score_spread":0.2026520724934718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}