{"id":"W4386747582","doi":"10.2174/0929867331666230913165219","title":"Three Decades of Targeting Falcipains to Develop AntiplasmodialAgents: What have we Learned and What can be Done Next?","year":2023,"lang":"en","type":"article","venue":"Current Medicinal Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Proteases; Malaria; Plasmodium falciparum; Drug discovery; Computational biology; Biology; Antimalarial Agent; Cysteine Proteinase Inhibitors; Pharmacology; Bioinformatics; Biochemistry; Enzyme; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003488326,0.0008605357,0.001249198,0.001001272,0.0005979716,0.002744184,0.0008450151,0.001809055,0.003323318],"category_scores_gemma":[0.003094807,0.0003887296,0.0008886161,0.0009931518,0.001745602,0.004942483,0.001254795,0.00404276,0.001269272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001185472,"about_ca_system_score_gemma":0.002166222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001383667,"about_ca_topic_score_gemma":0.002538129,"domain_scores_codex":[0.9993815,0.0001782611,0.00008470742,0.0001094036,0.0001356857,0.0001103562],"domain_scores_gemma":[0.9975232,0.001269913,0.000240147,0.0001435967,0.0005819763,0.0002411122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004861657,0.0003140826,0.00141837,0.0106783,0.0002670062,0.0004210474,0.0005954378,0.001457748,0.01414716,0.0229921,0.03028265,0.91694],"study_design_scores_gemma":[0.00009756906,0.002220828,0.002207599,0.006032102,0.0004799019,0.001640059,0.001167761,0.001030189,0.01521612,0.02366277,0.9461212,0.0001239591],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003587388,0.975329,0.00280009,0.01443946,0.001106061,0.00002591045,0.00008771136,0.00007077522,0.00255353],"genre_scores_gemma":[0.01907611,0.9655029,0.003756405,0.007945327,0.001331432,0.00004117086,0.0001648983,0.00003042174,0.00215124],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003488326,"threshold_uncertainty_score":0.01844829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1134005918158165,"score_gpt":0.3784464901569374,"score_spread":0.2650458983411209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}