{"id":"W4386754302","doi":"10.1021/acs.biomac.3c00630","title":"Self-Immolative Polymer Nanoparticles with Precise and Controllable pH-Dependent Degradation","year":2023,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Australian Research Council; Canada Research Chairs","keywords":"Depolymerization; Polymer; Chemistry; Nanoparticle; Methacrylate; Polymer chemistry; Particle (ecology); Ethylene glycol; Chemical engineering; Amine gas treating; Nanotechnology; Polymerization; Organic chemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009292446,0.0001517573,0.0001198957,0.00006005199,0.00009671611,0.00005737194,0.0001014672,0.00007886408,0.00001005152],"category_scores_gemma":[0.00001613832,0.0001222334,0.00003309496,0.0001463487,0.00006681599,0.000008989132,0.00008130677,0.00003124247,0.00005068705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007628641,"about_ca_system_score_gemma":0.0000429786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003310601,"about_ca_topic_score_gemma":0.00009101531,"domain_scores_codex":[0.9991093,0.00004689179,0.0001350685,0.0003386035,0.0001272699,0.0002428513],"domain_scores_gemma":[0.9995853,0.00001235149,0.00005751324,0.000196,0.0000732929,0.00007553583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001794923,0.00003743957,0.00187351,0.00001126327,0.0001066234,0.00001965953,0.00008321873,0.000003934909,0.995072,0.00006183756,0.0005552936,0.001995744],"study_design_scores_gemma":[0.0007745186,0.0004510112,0.002782931,0.00001483393,0.00003252803,0.00003083909,0.0001797732,0.0001809015,0.9940965,0.00003593888,0.0012326,0.0001876876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997629,0.001188925,0.0001650779,0.0001578795,0.00005193222,0.0001812497,0.00003041621,0.0000595127,0.0005359333],"genre_scores_gemma":[0.9978498,0.0002835088,0.0002865813,0.00009159585,0.00005174454,0.00003778778,0.00009384876,0.0000206685,0.001284451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001808056,"threshold_uncertainty_score":0.4984534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008229523728957298,"score_gpt":0.2269113945823344,"score_spread":0.2186818708533771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}