{"id":"W4386754302","doi":"10.1021/acs.biomac.3c00630","title":"Self-Immolative Polymer Nanoparticles with Precise and Controllable pH-Dependent Degradation","year":2023,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Australian Research Council; Canada Research Chairs","keywords":"Depolymerization; Polymer; Chemistry; Nanoparticle; Methacrylate; Polymer chemistry; Particle (ecology); Ethylene glycol; Chemical engineering; Amine gas treating; Nanotechnology; Polymerization; Organic chemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001532828,0.0003583962,0.0001740665,0.0001177792,0.00005670125,0.0001805,0.0001584642,0.0003235799,0.0003665898],"category_scores_gemma":[0.0001888929,0.0001882033,0.0001840099,0.00008092241,0.0001575089,0.0002542041,0.0001898671,0.0002797321,0.0002609362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001903721,"about_ca_system_score_gemma":0.0001346658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001787781,"about_ca_topic_score_gemma":0.000282895,"domain_scores_codex":[0.9998946,0.0000129911,0.000009811565,0.00003049561,0.00003144013,0.00002069698],"domain_scores_gemma":[0.9998956,0.00001834264,0.00004044835,0.00001195967,0.00001908488,0.00001464762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001316169,0.000004859779,0.00004872613,0.00002232643,0.000002226737,0.00001383971,0.000005320662,0.00004900219,0.9987386,0.00004911279,0.00001051583,0.001042309],"study_design_scores_gemma":[0.000003648299,0.00006371068,0.0005234546,0.000001187924,0.000004295566,0.00005754397,0.000002338532,0.0004456475,0.998248,0.00001391128,0.0006340748,0.000002174211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807849,0.001641585,0.01512814,0.00005707515,0.00002248551,0.00004640433,0.00009372968,0.0001405976,0.002085153],"genre_scores_gemma":[0.9839272,0.0007774041,0.01241308,0.00004759703,0.00001019007,0.00006989514,0.0001583313,0.00003294071,0.002563449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003665898,"threshold_uncertainty_score":0.001381278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008229523728957298,"score_gpt":0.2269113945823344,"score_spread":0.2186818708533771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}