{"id":"W4386757146","doi":"10.15252/embr.202357250","title":"Casein kinase 1 and 2 phosphorylate Argonaute proteins to regulate miRNA‐mediated gene silencing","year":2023,"lang":"en","type":"article","venue":"EMBO Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Deutsche Forschungsgemeinschaft","keywords":"Argonaute; Casein kinase 2; Gene silencing; Biology; RNA-induced silencing complex; Cell biology; Phosphorylation; Kinase; RNA interference; Protein kinase A; Gene; Biochemistry; Mitogen-activated protein kinase kinase; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004403693,0.0007239197,0.0003185014,0.0005588428,0.0003373173,0.0008599951,0.0003327841,0.0004089961,0.002370746],"category_scores_gemma":[0.000367168,0.000459435,0.0004935986,0.0001989867,0.0003832958,0.0006964211,0.0006520741,0.000725875,0.00100446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009127015,"about_ca_system_score_gemma":0.0003605694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004622701,"about_ca_topic_score_gemma":0.00129599,"domain_scores_codex":[0.9997297,0.00003563436,0.00001614373,0.00006314048,0.00006785474,0.00008767642],"domain_scores_gemma":[0.9998593,0.00003127231,0.00004086902,0.00001296173,0.00001742331,0.0000381469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004874236,0.00002295943,0.0006276345,0.00008341969,0.00002343076,0.0002033636,0.00003927808,0.0002116219,0.9936519,0.001397489,0.0004867125,0.002764744],"study_design_scores_gemma":[0.00009265509,0.00009493451,0.01661045,0.0000115359,0.00002896093,0.0005931164,0.00006848761,0.002591985,0.9712116,0.00106351,0.007610389,0.00002243194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9540883,0.01577193,0.01338986,0.0009167675,0.00051104,0.0000684722,0.0007563855,0.0004100898,0.0140871],"genre_scores_gemma":[0.9854534,0.001911961,0.002820567,0.0001877461,0.00008305268,0.00005849117,0.000768282,0.0000715724,0.008644884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002370746,"threshold_uncertainty_score":0.007930934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122107937265464,"score_gpt":0.2607676585435411,"score_spread":0.2495465791708864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}