{"id":"W4386757146","doi":"10.15252/embr.202357250","title":"Casein kinase 1 and 2 phosphorylate Argonaute proteins to regulate miRNA‐mediated gene silencing","year":2023,"lang":"en","type":"article","venue":"EMBO Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Deutsche Forschungsgemeinschaft","keywords":"Argonaute; Casein kinase 2; Gene silencing; Biology; RNA-induced silencing complex; Cell biology; Phosphorylation; Kinase; RNA interference; Protein kinase A; Gene; Biochemistry; Mitogen-activated protein kinase kinase; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004944369,0.0001609661,0.0001634073,0.00009876129,0.0001371764,0.00004439095,0.00008048533,0.0001111837,0.0000171477],"category_scores_gemma":[0.0002391254,0.0001522624,0.00005688872,0.0002824432,0.00003869914,0.000005387981,0.0002141445,0.00009848119,0.00003739447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001931283,"about_ca_system_score_gemma":0.00008959288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000210966,"about_ca_topic_score_gemma":0.00006552696,"domain_scores_codex":[0.9984487,0.00003832385,0.000286099,0.0005292017,0.0002314069,0.0004662633],"domain_scores_gemma":[0.9990311,0.000009752429,0.00008749923,0.0004741304,0.00007887645,0.0003186778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004447015,0.00001368243,0.0009798001,0.00001994576,0.0000295293,0.002491541,0.00008310617,0.00007824004,0.9896722,0.000003279405,0.003306281,0.003277958],"study_design_scores_gemma":[0.000252977,0.0002443688,0.01685368,0.00003589128,0.000008359553,0.0004125572,0.00008198099,0.000324495,0.9621541,0.00006724179,0.01928485,0.0002795104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980505,0.0005044281,0.00007315335,0.0004443739,0.0001670618,0.0004249219,0.00001153408,0.00005895775,0.0002650543],"genre_scores_gemma":[0.9922537,0.0002182582,0.000392993,0.0001811285,0.0002282867,0.00008011026,0.0001534362,0.00003622806,0.00645588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02751809,"threshold_uncertainty_score":0.6209081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122107937265464,"score_gpt":0.2607676585435411,"score_spread":0.2495465791708864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}