{"id":"W4386764722","doi":"10.1101/2023.09.12.557448","title":"Protein expression profiles in brain organoids are more similar to those in human brain parenchyma than in mouse brain parenchyma","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Alzheimer Society; Saskatchewan Health Research Foundation","keywords":"Organoid; Human brain; Parenchyma; Induced pluripotent stem cell; Biology; Neuroscience; Brain Cell; Cell biology; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001998089,0.0003174231,0.00021149,0.0006713834,0.0001857654,0.0005234535,0.000138097,0.0002166269,0.002827432],"category_scores_gemma":[0.000153297,0.0001546389,0.0003358072,0.0002881882,0.0002894507,0.0002433421,0.0003336654,0.0005888405,0.0009977364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002412116,"about_ca_system_score_gemma":0.0002552864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006271609,"about_ca_topic_score_gemma":0.0009535385,"domain_scores_codex":[0.999798,0.00001710136,0.0000200459,0.00008021574,0.00005944193,0.00002519329],"domain_scores_gemma":[0.9998154,0.00003260892,0.00004979646,0.00002638022,0.00002992286,0.00004586034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003821301,0.000003276208,0.0004206121,0.00001606495,0.000009879053,0.00003382151,0.00001624675,0.00001783428,0.9986404,0.0000434192,0.00003255159,0.0007277512],"study_design_scores_gemma":[0.000006051792,0.000122674,0.04054812,0.00001633002,0.00005865517,0.001039476,0.0001646458,0.0003522289,0.9498086,0.0001446235,0.007729105,0.000009544578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695303,0.002858444,0.0185039,0.0001930132,0.00007773859,0.0000487343,0.003896351,0.0003570417,0.004534448],"genre_scores_gemma":[0.9652203,0.002229428,0.01330079,0.0001403586,0.00001508294,0.0001200718,0.007721462,0.0002679097,0.01098467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002827432,"threshold_uncertainty_score":0.009458721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384964592047988,"score_gpt":0.2770856750749463,"score_spread":0.2532360291544664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}