{"id":"W4386765159","doi":"10.1038/s41467-023-41480-7","title":"Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Hospital for Sick Children; McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institutes of Health; Narodowym Centrum Nauki; U.S. Department of Health and Human Services; Government of Canada; McGill University; Welch Foundation; Natural Sciences and Engineering Research Council of Canada; Narodowe Centrum Nauki","keywords":"Mechanism (biology); Dynein; Computational biology; Cell biology; Biology; Microtubule; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003216552,0.0001275941,0.0001420221,0.00006414526,0.0002379223,0.00001141107,0.001291834,0.0003827402,0.000007331723],"category_scores_gemma":[0.0001457164,0.0001044457,0.0001379995,0.0003708259,0.0001025256,0.000004360804,0.0007266447,0.0004384838,0.000009253438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002191284,"about_ca_system_score_gemma":0.0001042679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009613729,"about_ca_topic_score_gemma":0.0001639969,"domain_scores_codex":[0.9990549,0.0001791632,0.0002666668,0.000197887,0.0001330414,0.0001683256],"domain_scores_gemma":[0.9972686,0.00002665389,0.0001191627,0.002280805,0.00026417,0.00004057074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008056347,0.00003489432,0.000151519,0.00001285053,0.00004668541,9.718756e-8,0.00005580303,0.00044788,0.9642162,0.02661056,0.008235764,0.0001797341],"study_design_scores_gemma":[0.001524075,0.0001679373,0.02121559,0.0003975877,0.0002358848,0.00003245061,0.001214216,0.3132564,0.485249,0.01022383,0.165279,0.001204078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909075,0.003959719,0.0006200245,0.001781336,0.0002186458,0.0004245067,0.0001461431,0.00006450435,0.001877651],"genre_scores_gemma":[0.9956682,0.0009451102,0.001323152,0.0004712205,0.00003952124,0.00002580389,0.0005477372,0.00002601926,0.0009532274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4789672,"threshold_uncertainty_score":0.4259171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03150961901988918,"score_gpt":0.2883914758548564,"score_spread":0.2568818568349672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}