{"id":"W4386765159","doi":"10.1038/s41467-023-41480-7","title":"Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Hospital for Sick Children; McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institutes of Health; Narodowym Centrum Nauki; U.S. Department of Health and Human Services; Government of Canada; McGill University; Welch Foundation; Natural Sciences and Engineering Research Council of Canada; Narodowe Centrum Nauki","keywords":"Mechanism (biology); Dynein; Computational biology; Cell biology; Biology; Microtubule; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001192252,0.0004091961,0.0003282383,0.0002374835,0.0003362737,0.000567676,0.0006054839,0.000480499,0.0022325],"category_scores_gemma":[0.0001360531,0.0002544869,0.0003686048,0.0002015409,0.0002640225,0.0003079738,0.0002194609,0.0003334898,0.0003139557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007683416,"about_ca_system_score_gemma":0.0008148821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01101169,"about_ca_topic_score_gemma":0.005872453,"domain_scores_codex":[0.9999522,0.000007051107,0.000002200502,0.0000145973,0.00001262296,0.00001134575],"domain_scores_gemma":[0.9999567,0.00000794502,0.000009594231,0.000005213225,0.00001074159,0.000009890888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001439734,0.00005990281,0.001695896,0.00004577891,0.00002989549,0.0002014416,0.00005423372,0.9364906,0.04265219,0.01503681,0.0003082828,0.00328107],"study_design_scores_gemma":[0.0000131946,0.00001118277,0.0003742584,0.000001278614,0.000005210672,0.000008495305,0.000009104472,0.9971868,0.001245123,0.0006835638,0.000458476,0.000003289143],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8649834,0.000505811,0.1088906,0.0002531783,0.000046291,0.00005691865,0.0007985023,0.0008729924,0.02359232],"genre_scores_gemma":[0.9839159,0.0002048301,0.01370892,0.00002173167,0.000005882116,0.00004881878,0.0003076645,0.00007793247,0.001708411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01101169,"threshold_uncertainty_score":0.02189517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03150961901988918,"score_gpt":0.2883914758548564,"score_spread":0.2568818568349672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}