{"id":"W4386765496","doi":"10.1002/wps.21120","title":"Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions","year":2023,"lang":"en","type":"article","venue":"World Psychiatry","topic":"Treatment of Major Depression","field":"Medicine","cited_by":690,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brain and Cognition Discovery Foundation; University of Toronto","funders":"National Center for Advancing Translational Sciences","keywords":"Medicine; Quetiapine; Aripiprazole; Psychological intervention; Treatment-resistant depression; Olanzapine; Psychiatry; Clinical trial; Depression (economics); Intensive care medicine; Antidepressant; Schizophrenia (object-oriented programming); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01153851,0.0008998578,0.001940609,0.004851226,0.0006640744,0.002829528,0.001555994,0.001963116,0.001025195],"category_scores_gemma":[0.02142373,0.0005500228,0.0009033616,0.005199871,0.001571369,0.00282951,0.001763779,0.002096878,0.0002941924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003793324,"about_ca_system_score_gemma":0.004806431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003413066,"about_ca_topic_score_gemma":0.003706356,"domain_scores_codex":[0.9905095,0.004163339,0.002399759,0.0008165092,0.001841938,0.000268904],"domain_scores_gemma":[0.9892489,0.004730022,0.00312004,0.0002386038,0.002126181,0.0005362377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003862859,0.000739361,0.07839049,0.01687241,0.000351231,0.0002770866,0.0008178425,0.0007711144,0.0004182205,0.01942404,0.02347388,0.8580781],"study_design_scores_gemma":[0.0005510228,0.002284008,0.6036896,0.1233462,0.001896312,0.01070113,0.005325938,0.01074347,0.0009651172,0.0582508,0.1818405,0.0004059824],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02071006,0.9181804,0.007990422,0.04175962,0.0005751234,0.001090332,0.001152954,0.00005432727,0.008486813],"genre_scores_gemma":[0.24057,0.7248163,0.01983749,0.006890635,0.002358429,0.003039779,0.001813269,0.00002661036,0.0006474464],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01153851,"threshold_uncertainty_score":0.06102216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04151835586725389,"score_gpt":0.3045115093049669,"score_spread":0.262993153437713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}