{"id":"W4386765496","doi":"10.1002/wps.21120","title":"Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions","year":2023,"lang":"en","type":"article","venue":"World Psychiatry","topic":"Treatment of Major Depression","field":"Medicine","cited_by":690,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brain and Cognition Discovery Foundation; University of Toronto","funders":"National Center for Advancing Translational Sciences","keywords":"Medicine; Quetiapine; Aripiprazole; Psychological intervention; Treatment-resistant depression; Olanzapine; Psychiatry; Clinical trial; Depression (economics); Intensive care medicine; Antidepressant; Schizophrenia (object-oriented programming); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007760305,0.0001929797,0.0001795445,0.0005317102,0.000273602,0.00003366748,0.0000599327,0.00005296987,0.0003353924],"category_scores_gemma":[0.00001444571,0.0001598417,0.0001557338,0.0007282206,0.0000847323,0.0001102261,0.00005609201,0.00009390809,0.0002416933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006942773,"about_ca_system_score_gemma":0.00003803537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008943883,"about_ca_topic_score_gemma":0.0001611516,"domain_scores_codex":[0.9987605,0.00004904674,0.0003077913,0.0004099668,0.0002521328,0.0002205701],"domain_scores_gemma":[0.999298,0.00004492737,0.00009858886,0.0003420272,0.00003659632,0.0001798966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003155602,0.0006379229,0.9511982,0.001143369,0.0004041266,0.00006166313,0.00008054513,0.000004401303,0.0003970994,0.009009997,0.02192515,0.01482193],"study_design_scores_gemma":[0.002967511,0.0002369983,0.9741126,0.0009919563,0.0005014281,0.00006601789,0.00008682869,0.00003739721,0.0002317809,0.009875933,0.01073761,0.0001538942],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9121306,0.008232776,0.0003015436,0.00713442,0.001970551,0.001665161,0.0001080984,0.001320377,0.06713647],"genre_scores_gemma":[0.9531869,0.0006569693,0.007417049,0.0002122369,0.0002436017,0.0003493314,0.0001512713,0.00004004767,0.03774258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0410563,"threshold_uncertainty_score":0.6518157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04151835586725389,"score_gpt":0.3045115093049669,"score_spread":0.262993153437713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}