{"id":"W4386766975","doi":"10.1371/journal.ppat.1011182","title":"The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Malaria Research and Control","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; FP7 Research infrastructures; Canadian Institutes of Health Research; Rhodes Scholarships; LifeArc; Burnet Institute; Wellcome Trust; National Health and Medical Research Council; European Commission","keywords":"Basigin; Plasmodium falciparum; Epitope; Monoclonal antibody; Biology; Antibody; Extracellular; Cell biology; Virology; Immunology; Malaria; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004580359,0.0001309802,0.0002544945,0.0001708635,0.0004134059,0.00005166203,0.00005442083,0.00006408069,0.00001577944],"category_scores_gemma":[0.0004058031,0.00009474795,0.00004072223,0.0002604138,0.00009664702,0.00006701722,0.0001379514,0.0001918072,0.000009689448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002467862,"about_ca_system_score_gemma":0.00002661821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002320864,"about_ca_topic_score_gemma":0.00003056269,"domain_scores_codex":[0.9987156,0.00007826873,0.0002402339,0.0002654831,0.0003599096,0.0003405247],"domain_scores_gemma":[0.999118,0.0003330882,0.00007855856,0.0002138164,0.0001058973,0.0001506632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001723025,0.00004375682,0.01805474,0.0001104545,0.00006523314,0.00005240094,0.0006456273,0.000002366858,0.9753249,0.0006038021,0.0001597113,0.004764763],"study_design_scores_gemma":[0.002207164,0.001154729,0.2766694,0.0005069156,0.0001421638,0.00005254337,0.006193747,0.002753802,0.7077614,0.00041525,0.001848147,0.0002947136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996615,0.0007140132,0.00003071596,0.001769655,0.00004160831,0.0004873735,0.00001527519,0.00005662936,0.0002697245],"genre_scores_gemma":[0.9986817,0.0005308604,0.0001395429,0.00001894842,0.0001233962,0.00002988882,0.00001623979,0.00002099875,0.0004384886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2675634,"threshold_uncertainty_score":0.3863709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07300134009592237,"score_gpt":0.3095862575450334,"score_spread":0.2365849174491111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}