{"id":"W4386766975","doi":"10.1371/journal.ppat.1011182","title":"The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Malaria Research and Control","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; FP7 Research infrastructures; Canadian Institutes of Health Research; Rhodes Scholarships; LifeArc; Burnet Institute; Wellcome Trust; National Health and Medical Research Council; European Commission","keywords":"Basigin; Plasmodium falciparum; Epitope; Monoclonal antibody; Biology; Antibody; Extracellular; Cell biology; Virology; Immunology; Malaria; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002629807,0.0006545671,0.0003067805,0.0001525618,0.0001202294,0.0002451221,0.0003300561,0.0005178699,0.0008652247],"category_scores_gemma":[0.000196678,0.0002396539,0.0003242469,0.0000879353,0.0002072915,0.0002207402,0.000202878,0.0007581938,0.0002489466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003801887,"about_ca_system_score_gemma":0.0002109126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008467654,"about_ca_topic_score_gemma":0.001180551,"domain_scores_codex":[0.9997104,0.00005067985,0.00001538665,0.00006947466,0.00005802915,0.00009604909],"domain_scores_gemma":[0.9998968,0.00003590381,0.0000208401,0.00001203194,0.0000133092,0.00002110586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000564983,0.00001811063,0.00005163599,0.000028439,0.000003807387,0.00001489402,0.000005094613,0.00003078358,0.9986607,0.00004945011,0.00002784894,0.001052697],"study_design_scores_gemma":[0.00002026111,0.0003343233,0.001791056,0.000004341703,0.00001359421,0.0001961714,0.000004928209,0.0009750174,0.9952434,0.00001471611,0.001399527,0.000002621524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809318,0.003671533,0.01196477,0.0001670509,0.00004635431,0.00007058705,0.0001444138,0.0001656343,0.002837935],"genre_scores_gemma":[0.9832825,0.001151243,0.01290885,0.0001384639,0.00002890117,0.00008253215,0.0002648235,0.00002313287,0.002119564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008652247,"threshold_uncertainty_score":0.002894461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07300134009592237,"score_gpt":0.3095862575450334,"score_spread":0.2365849174491111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}