{"id":"W4386769475","doi":"10.1016/j.celrep.2023.113084","title":"CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canada Research Chairs; Cole Foundation; Fonds de Recherche du Québec - Santé; Hydro-Québec; Canadian Cancer Society; Fondation de l’Hôpital Maisonneuve-Rosemont; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Acute megakaryoblastic leukemia; Cancer research; Mutation; Phenotype; Medicine; Gene; Biology; Myeloid leukemia; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005027451,0.0003675068,0.0005922994,0.0003786389,0.0001585833,0.0000777176,0.0001213057,0.0002543959,0.0001384928],"category_scores_gemma":[0.0003627194,0.0003371779,0.0001390971,0.0009605102,0.0001061911,0.0001183297,0.0004743582,0.0004372395,0.0005955164],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007786078,"about_ca_system_score_gemma":0.005180095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004649998,"about_ca_topic_score_gemma":0.00001864597,"domain_scores_codex":[0.9960877,0.00005906328,0.0006527052,0.001074793,0.001218865,0.0009068811],"domain_scores_gemma":[0.9974887,0.0002818698,0.0001989673,0.0008843907,0.0002720541,0.0008740159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006333512,0.0002081646,0.01069541,0.001061066,0.000464443,0.1481105,0.004708509,0.0003520749,0.1022988,0.00001133486,0.7283024,0.003154023],"study_design_scores_gemma":[0.04354113,0.004497289,0.02893074,0.0009569273,0.004589523,0.05104024,0.003496832,0.0415106,0.7358331,0.0005832659,0.08040775,0.00461257],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924484,0.0002947256,0.00008580687,0.0004234902,0.0005214539,0.001148071,0.00004599972,0.0002816149,0.004750474],"genre_scores_gemma":[0.96397,0.0005317332,0.000167014,0.0005798502,0.0005314372,0.00007800766,0.0001345351,0.0001001904,0.03390725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6478947,"threshold_uncertainty_score":0.999908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019570939743706,"score_gpt":0.2766451652075693,"score_spread":0.2664494558101322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}