{"id":"W4386769475","doi":"10.1016/j.celrep.2023.113084","title":"CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canada Research Chairs; Cole Foundation; Fonds de Recherche du Québec - Santé; Hydro-Québec; Canadian Cancer Society; Fondation de l’Hôpital Maisonneuve-Rosemont; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Acute megakaryoblastic leukemia; Cancer research; Mutation; Phenotype; Medicine; Gene; Biology; Myeloid leukemia; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001100958,0.0003838489,0.0002320167,0.0002637905,0.0001528982,0.0002673829,0.0001499932,0.0002293321,0.001317048],"category_scores_gemma":[0.0000660587,0.0001500331,0.0002752489,0.0001776227,0.0002817234,0.0001407145,0.0001825676,0.0006245756,0.0002808783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003592613,"about_ca_system_score_gemma":0.0002349267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001061643,"about_ca_topic_score_gemma":0.002390006,"domain_scores_codex":[0.9998578,0.00001980837,0.00001294476,0.00002206254,0.00005026977,0.00003697558],"domain_scores_gemma":[0.9999043,0.0000104944,0.00003872749,0.000008250547,0.000005558936,0.00003264234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009397144,0.00002184934,0.0003819886,0.00001374318,0.000005907949,0.0001047327,0.00001432017,0.00007864707,0.9985281,0.0001395819,0.00004055163,0.000576539],"study_design_scores_gemma":[0.00006915867,0.0006273869,0.008876059,0.000007033614,0.00002352202,0.001654087,0.00005661855,0.001362477,0.983727,0.00006704692,0.003523703,0.00000588433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962838,0.0004072366,0.001631425,0.0000810748,0.00001415997,0.00003999929,0.0004708304,0.00008106397,0.0009903371],"genre_scores_gemma":[0.9959858,0.0003627267,0.001448831,0.00004452849,0.000006064275,0.00005776886,0.0007676921,0.00002857885,0.001298045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001317048,"threshold_uncertainty_score":0.004405975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019570939743706,"score_gpt":0.2766451652075693,"score_spread":0.2664494558101322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}